NDLI: Lack of effects of isoflavones on the lipid profile of Brazilian postmenopausal women.

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Lack of effects of isoflavones on the lipid profile of Brazilian postmenopausal women.

Year: 2007 Volume: 23

Year: 2006 Volume: 22

Lack of effects of isoflavones on the lipid profile of Brazilian postmenopausal women.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rios, Danyelle Romana A. Rodrigues, Edna T. Cardoso, Ana Paula Z. Montes, Marlise Boneti A. Franceschini, Sílvio A. Toloi, Maria Regina T.
Spatial Coverage	Brazil
Description	Country affiliation: Brazil Author Affiliation: Rios DR ( Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.)
Abstract	OBJECTIVE: To evaluate the effects of soy isoflavone supplementation on profile lipid and endogenous hormone levels. METHODS: In this double-blind, placebo-controlled study, 47 postmenopausal women 47-66 y of age received 40 mg of isoflavone (n = 25) or 40 mg of casein placebo (n = 22). Cardiovascular risk factors were assessed by evaluating lipid profile at baseline and after 6 mo of treatment. To examine the effects of this regime on endogenous hormone levels, follicle-stimulating hormone and beta-estradiol were measured. Urinary isoflavone concentrations (genistein and daidzein) were measured as markers of both compliance and absorption using high performance liquid chromatography. Baseline characteristics were compared by the unpaired Student's t-test. Within-group changes were determined by paired Student's t-test and comparison between the isoflavone and casein placebo groups were determined by analysis of variance. RESULTS: Lipid levels (low-density lipoprotein and total cholesterol) similarly decreased in both groups. High-density lipoprotein increased significantly in both groups and cannot thus be attributable to treatment; the reason for such variation is unknown and can be attributed to chance or to bias (even that of a real placebo effect in both groups or perhaps in spontaneous changes in exercise and dietary habits of patients after their inclusion). Furthermore, in both groups very low-density lipoprotein and triacylglycerol levels increased in a non-significant manner. CONCLUSION: The results of the present study do not support any biologically significant estrogenic effects of isoflavone on the parameters assessed. Further research will be necessary to definitively assess the safety and efficacy of isoflavone.
File Format	HTM / HTML
ISSN	08999007
Issue Number	11-12
Volume Number	24
e-ISSN	18731244
Journal	Nutrition
Language	English
Publisher	Elsevier
Publisher Date	2008-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nutritional Sciences Cardiovascular Diseases Prevention & Control Cholesterol Blood Hypercholesterolemia Isoflavones Administration & Dosage Postmenopause Aged Analysis Of Variance Biological Markers Urine Brazil Caseins Cholesterol, Hdl Cholesterol, Ldl Chromatography, High Pressure Liquid Dietary Supplements Double-blind Method Estrogens, Non-steroidal Female Genistein Humans Middle Aged Patient Compliance Drug Effects Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Endocrinology, Diabetes and Metabolism

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