NDLI: A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial.

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A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Barrat, Emmanuel Zaïr, Yassine Ogier, Nicolas Housez, Béatrice Vergara, Coralie Maudet, Corinne Lescuyer, Jean-François Bard, Jean-Marie Carpentier, Yvon A. Cazaubiel, Murielle Peltier, Sébastien L.
Description	Country affiliation: France Author Affiliation: Barrat E ( Department of Research and Development, Laboratoire Lescuyer , Aytré , France .)
Abstract	OBJECTIVE: To investigate the effect of a natural cholesterol-lowering supplement (NCLS) containing red yeast rice, policosanols and artichoke leaf extracts on blood lipid concentrations as well as on safety parameters when given over 16 weeks in 100 volunteers with untreated moderate hypercholesterolemia, in a randomized, double-blind, placebo-controlled trial. RESULTS: Reduction of primary outcome low-density lipoprotein cholesterol [-0.22 g/L (95% confidence interval, CI: -0.31 to -0.12) corresponding to -14.3% from baseline (95% CI: -21.5 to -7.2) compared to placebo], as well as total cholesterol, apolipoprotein B100 and apolipoprotein B100/apolipoprotein A-I ratio, were observed after 16 weeks of supplementation with NCLS. These effects were already observed at Week 4 and 10 of supplementation. No significant changes were observed in high-density lipoprotein, triacylglycerol, creatine kinase, lactate dehydrogenase and coenzyme Q10 levels, as well as in markers of liver and renal function. CONCLUSIONS: The NCLS was effective in reducing low-density lipoprotein cholesterol and apolipoprotein B100 in subjects with moderate hypercholesterolemia, without modifying safety parameters.
File Format	HTM / HTML
ISSN	09637486
Issue Number	7
Volume Number	64
e-ISSN	14653478
Journal	International Journal of Food Sciences and Nutrition
Language	English
Publisher	Taylor & Francis
Publisher Date	2013-11-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nutritional Sciences Apolipoprotein B-100 Blood Biological Products Therapeutic Use Cholesterol, Ldl Cynara Scolymus Fatty Alcohols Hypercholesterolemia Drug Therapy Plant Extracts Adult Anticholesteremic Agents Pharmacology Apolipoprotein A-i Cholesterol Cholesterol, Hdl Dietary Supplements Double-blind Method Female Humans Male Middle Aged Phytotherapy Triglycerides Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Food Science

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