NDLI: Coronary artery bypass graft surgery depletes plasma thiamine levels.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Donnino, Michael W. Cocchi, Michael N. Smithline, Howard Carney, Erin Chou, Peter P. Salciccioli, Justin Salciccoli, Justin
Description	Country affiliation: United States Author Affiliation: Donnino MW ( Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. mdonnino@bidmc.harvard.edu)
Abstract	OBJECTIVE: Thiamine is an essential component of cellular metabolism, and lack of this vitamin results in a potentially life-threatening biochemical lesion. The stress of surgery and critical disease depletes electrolytes, minerals, and essential biochemical substrates. We hypothesized that critical illness (represented by major surgery) would result in decreased thiamine levels over time. METHODS: We performed a prospective, observational study of serial thiamine levels of 15 patients who underwent non-emergent coronary artery bypass graft surgery. The primary endpoint was change in thiamine levels from before to immediately after surgery. Secondary endpoints included change in thiamine levels from presurgical to 6- and 24-h time points. RESULTS: Of the 15 study patients, 1 did not have a plasma thiamine measurement at time 0 because of laboratory error and could not be accounted for in paired comparisons over time. Plasma thiamine levels decreased significantly from before to after coronary artery bypass grafting (P=0.0004). In addition, there was a statistically significant decrease in thiamine levels from before surgery to 24h (P=0.003). CONCLUSION: Our data suggest that major surgery (as a surrogate for the stress of critical illness) depletes thiamine levels; further study is needed to determine whether routine replacement of thiamine in the critically ill is warranted.
File Format	HTM / HTML
ISSN	08999007
e-ISSN	18731244
DOI	10.1016/j.nut.2009.06.004
Journal	Nutrition
Issue Number	1
Volume Number	26
Language	English
Publisher	Elsevier
Publisher Date	2010-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Nutritional Sciences Coronary Artery Bypass Postoperative Complications Blood Thiamine Observation Prospective Studies Time Factors
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Endocrinology, Diabetes and Metabolism

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