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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Huang, Tao Wahlqvist, Mark L. Li, Duo |
| Description | Country affiliation: China Author Affiliation: Huang T ( Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.) |
| Abstract | OBJECTIVE: The objective of this study was to investigate the regulatory effect of fish oil rich in omega-3 polyunsaturated fatty acids (PUFAs) on critical enzyme activity and mRNA expression involved in homocysteine (Hcy) metabolism. METHODS: Thirty-six male Sprague-Dawley rats aged 3 wk, weighing 120 +/- 10 g, were randomly divided into three groups: the olive oil (OO) group, the tuna oil (TO) group, and the salmon oil (SO) group. The oil was orally administered every day using a stomach tube. Eight weeks later, plasma Hcy, phospholipids, omega-3 PUFAs, enzyme activity, and mRNA expression in tissues were determined. RESULTS: Compared with the control group, phospholipids, total omega-3 PUFAs, and omega-3/omega-6 PUFAs in the liver and lung were significantly elevated in the TO and SO groups; 22:6omega-3 in the liver and lung was significantly increased in the TO group; and 20:5omega-3 in the two tissues was significantly elevated in the SO group. The level of plasma Hcy was significantly decreased with TO; methionine adenosyl transferase (MAT) activity was significantly increased and MAT mRNA expression was significantly upregulated with TO; cystathionine-gamma-lyase mRNA expression in TO was significantly upregulated; however, cystathionine beta-synthase and S-adenosylhomocysteine hydrolases were not significantly changed when compared with control. CONCLUSION: TO rich in 22:6omega-3 decreases the concentration of Hcy despite increasing MAT activity and upregulating MAT mRNA expression through compensatory cystathionine-gamma-lyase mRNA expression, both of which are involved in Hcy metabolism. |
| File Format | HTM / HTML |
| ISSN | 08999007 |
| Issue Number | 1 |
| Volume Number | 26 |
| e-ISSN | 18731244 |
| Journal | Nutrition |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Nutritional Sciences Docosahexaenoic Acids Pharmacology Enzymes Metabolism Gene Expression Drug Effects Homocysteine Blood Lipid Metabolism Methionine Adenosylhomocysteinase Genetics Animals Cystathionine Beta-synthase Cystathionine Gamma-lyase Administration & Dosage Fish Oils Liver Lung Male Methionine Adenosyltransferase Olive Oil Plant Oils Rna, Messenger Random Allocation Rats Rats, Sprague-dawley Salmon Tuna Up-regulation Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Endocrinology, Diabetes and Metabolism |
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