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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Demirkan, Arda Savas, Berna Melli, Mehmet |
| Description | Country affiliation: Turkey Author Affiliation: Demirkan A ( Ankara University Faculty of Medicine, Department of Emergency Medicine, Sihhiye, Ankara, Turkey.) |
| Abstract | OBJECTIVE: We aimed to investigate the effect of enteral glutamine (Gln) pretreatment on plasma endotoxin level and intestinal histopathologic changes during intestinal ischemia-reperfusion (I/R) injury in rats. METHODS: Intestinal I/R was induced by 60-min occlusion of the superior mesenteric artery followed by 60 min of reperfusion. Animals were pretreated with Gln by orogastric route for different periods and doses. To investigate the effects of gut decontamination on intestinal I/R injury, animals were pretreated with neomycin sulfate and erythromycin phosphate by orogastric route. In another series, dl-alpha-tocopherol hydrogen succinate was used to investigate the effects of vitamin E on intestinal I/R injury. Plasma endotoxin level was measured by the colorimetric 'limulus amebocyte lysate' test. Intestinal mucosal injury was scored on a scale described by Chiu et al. (Archive in Surgery 1970;101:478-483). RESULTS: Intestinal I/R increased the plasma endotoxin level and worsened the histopathologic score significantly. Gln pretreatment (1g/kg) for 4 d reduced the I/R-induced elevation of plasma endotoxin level. However, a significant improvement in histopathologic score could only be achieved when the pretreatment was given for 7 d. Antibiotic pretreatment lowered plasma endotoxin level without affecting the I/R-induced histopathologic changes, whereas vitamin E pretreatment affected plasma endotoxin level and histopathologic changes. CONCLUSION: These results suggest a lack of association between plasma endotoxin level and intestinal histopathologic alterations in intestinal I/R. |
| File Format | HTM / HTML |
| ISSN | 08999007 |
| Issue Number | 1 |
| Volume Number | 26 |
| e-ISSN | 18731244 |
| Journal | Nutrition |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Nutritional Sciences Anti-bacterial Agents Therapeutic Use Endotoxins Blood Glutamine Intestinal Mucosa Drug Effects Reperfusion Injury Drug Therapy Vitamin E Vitamins Animals Pharmacology Erythromycin Female Metabolism Pathology Mesenteric Artery, Superior Neomycin Rats Rats, Wistar Alpha-tocopherol Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Endocrinology, Diabetes and Metabolism |
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