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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jordan, S. Jackson, H. C. Nutt, D. J. Handley, S. L. |
| Description | Author Affiliation: Jordan S ( Pharmaceutical Sciences Institute, Aston University, Aston Triangle, Birmingham B4 7ET.) |
| Abstract | The technique of drug discrimination was used to examine the ability of the highly selective (2)-adrenoceptor antagonist ethoxy idazoxan, which has negligible affinity for ( 1)-adrenoceptors or I(2) imidazoline receptors, to produce an interoceptive discriminable stimulus or cue in rats. Rats were trained to respond on one lever after receiving -ethoxy idazoxan (2.5 mg/kg, i.p.) and on the opposite lever after saline vehicle. The ethoxy idazoxan cue appeared to be mediated by antagonists of central (2)-adrenoceptors, on the basis that dose- related substitution was produced by the highly selective (2)-adrenoceptor antagonists idazoxan (imidazoline), fluparoxan and 1-(2-pyrimidinyl) piperazine (1-PP) (both non-imidazoline) but not by clonidine, which acts as an agonist at this receptor, nor by the peripherally acting (2)-adrenoceptor antagonist L659,066. However, the (2)-adrenoceptor antagonists yohimbine and atipamezole showed partial and non-dose-dependent substitution for ethoxy idazoxan over a wide range of doses. 2-BFI [2-(2-benzfuranyl)-2-imidazoline, RX801077], an imidazoline which is highly selective for I(2) imidazoline receptors over (2)-adrenoceptors, showed dose- dependent substitution for ethoxy idazoxan, although the maximum effect (73% responding on the ethoxy idazoxan lever) fell short of criteria adopted for full substitution. Among other agents which bind to I(2) receptors, only idazoxan and 2-phenyl-2-imidazoline exhibited significant substitution; cirazoline could only be tested at very low doses because it powerfully inhibited responding in general, probably due to its (1)-adrenoceptor agonist properties. It is suggested that the ability of 2-BFI to substitute partially for ethoxy idazoxan might be due to the ability of both agents to increase extracellular concentrations of noradrenaline. |
| File Format | HTM / HTML |
| ISSN | 02698811 |
| Issue Number | 3 |
| Journal | Journal of Psychopharmacology |
| Volume Number | 9 |
| e-ISSN | 14617285 |
| Language | English |
| Publisher | SAGE Publications |
| Publisher Date | 1995-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) Psychiatry and Mental Health |
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