NDLI: The discriminative stimulus produced by pentylenetetrazol: effects of systemic anxiolytics and anxiogenics, aggressive defeat and midazolam or muscimol infused into the amygdala.

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Interactions of antidepressants and ethanol on spontaneous locomotor activity and rotarod performance in NMRI and C57BL/6 mice.

The scopolamine model of dementia: determination of central cholinomimetic effects of physostigmine on cognition and biochemical markers in man.

The discriminative stimulus produced by pentylenetetrazol: effects of systemic anxiolytics and anxiogenics, aggressive defeat and midazolam or muscimol infused into the amygdala.

Serum haloperidol levels and clinical response in chronic, treatment-resistant schizophrenic patients.

Abstracts from the summer meeting of the british association for psychopharmacology, held in cambridge, England 10-13 july 1988. The abstracts are arranged in alphabetical order by first author.

Year: 1988 Volume: 2 Issue: 1

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The discriminative stimulus produced by pentylenetetrazol: effects of systemic anxiolytics and anxiogenics, aggressive defeat and midazolam or muscimol infused into the amygdala.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Vellucci, S. V. Martin, P. J. Everitt, B. J.
Description	Country affiliation: United kingdom Author Affiliation: Vellucci SV ( Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.)
Abstract	Rats were trained to discriminate the interoceptive stimulus generated by systemic administration of pentylenetetrazol. A series of experiments confirmed earlier studies that rats generalized to the pentylenetetrazol cue following treatment with drugs purported to have anxiogenic properties, such as ß-carboline carboxylic acid (ßCCM) and FG 7142. The benzodiazepine antagonist, Ro 15-1788, did not generalize to the pentylenetetrazol cue. Anxiolytic drugs, such as the benzodiazepines chlordiazepoxide and midazolam, prevented discrimination of the pentylenetetrazol cue and resulted in generalization to the saline vehicle. Ritanserin, a 5-HT(2) receptor antagonist and putative anxiolytic compound, did not prevent discrimination of the pentylenetetrazol cue. Subjecting the rats to aggressive defeat in a home cage intruder test (following injection of saline) resulted in a significant proportion of them generalizing to the pentylenetetrazol discriminative stimulus. This result is discussed in terms of the suggested anxiogenic nature of the effects of treatment with pentylenetetrazol. Infusion of midazolam bilaterally into the amygdala antagonized, in a dose-dependent manner, dis crimination of the interoceptive stimulus generated by systemic treatment with FG 7142 (which itself generalized to the pentylenetetrazol cue). Furthermore, infusion of the GABA agonist, muscimol, bilaterally into the amygdala antagonized the pentylenetetrazol discri minative stimulus in a dose-dependent manner. These data suggest that amygdaloid mech anisms may be involved in the generation or discrimination of the distinctive, interoceptive stimuli associated with pentylenetetrazol and the ß-carboline, FG 7142. The data are discussed in the context of suggested functions of the amygdaloid complex in fear-motivated behaviour.
File Format	HTM / HTML
ISSN	02698811
Issue Number	2
Journal	Journal of Psychopharmacology
Volume Number	2
e-ISSN	14617285
Language	English
Publisher	SAGE Publications
Publisher Date	1988-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical) Psychiatry and Mental Health

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