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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dickinson, S. L. Tulloch, I. F. Gadie, B. |
| Description | Author Affiliation: Dickinson SL ( Reckitt and Colman Psychopharmacology Unit, The School of Medical Sciences, University Walk, Bristol BS8 1TD.) |
| Abstract | The (2)-adrenoceptor antagonists idazoxan and RX811059 induced reciprocal forepaw treading, a component of the 5-HT-behavioural syndrome in rats. This response is independent of 'non- (2)-adrenoceptor idazoxan binding sites' (NAIBS) at which RX811059 is inactive. Idazoxan pre-treatment, in rats, enhanced forepaw treading, head weaving and tremor induced by the 5-HT agonist 5-methoxy-N,N dimethyltryptamine (5-MeODMT), increased head twitches (but decreased hindlimb abduction) induced by the 5-HT releaser p- chloroamphetamine (pCA), but did not clearly alter head twitches induced by the 5-HT precursor L-5-hydroxytryptophan in mice. The (1)-antagonist prazosin did not alter behaviour induced by either 5-MeODMT or pCA in rats. The ( 2)-agonist, guanoxabenz, did not alter 5-MeODMT-induced behaviour in rats. St587, an (1)-agonist, selectively potentiated tremor induced by 5-MeODMT, but no other behaviour. A possible mechanism for these interactions could be through enhanced, (2)-adrenoceptor-mediated, 5-HT release in specific brain areas. Other possibilities, e.g. direct action at subtypes of 5-HT receptors and the importance of these NA-5-HT interactions in the treatment of resistant depression, are discussed. |
| File Format | HTM / HTML |
| ISSN | 02698811 |
| Issue Number | 3 |
| Journal | Journal of Psychopharmacology |
| Volume Number | 5 |
| e-ISSN | 14617285 |
| Language | English |
| Publisher | SAGE Publications |
| Publisher Date | 1991-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) Psychiatry and Mental Health |
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