| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Nagajyothi, P. C. Pandurangan, Muthuraman Sreekanth, T. V. M. Shim, Jaesool |
| Description |
Author Affiliation: Nagajyothi PC ( School of Mechanical Engineering, Yeungnam University, 214-1 Dae-dong, Gyeongsan-si, Gyeongsangbuk-do 712-749, Republic of Korea.); Pandurangan M ( Dept of Bioresources and Food Science, Konkuk University, Seoul, South Korea.); Sreekanth TV ( School of Chemical Engineering, Yeungnam University, 214-1 Dae-dong, Gyeongsan-si, Gyeongsangbuk-do 712-749, Republic of Korea. Electronic address: tvmsreekanth@gmail.com.); Shim J ( School of Mechanical Engineering, Yeungnam University, 214-1 Dae-dong, Gyeongsan-si, Gyeongsangbuk-do 712-749, Republic of Korea. Electronic address: jshim@ynu.ac.kr.) |
| Abstract |
Green synthesis of nanoparticles is a growing research area because of their potential applications in nanomedicine. Barium carbonate nanoparticles (BaCO3 NPs) were synthesized using an aqueous extract of Mangifera indica seed as a reducing agent. These particles were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Transmission electron microscopy (TEM), selected area electron diffraction (SAED), Energy-dispersive-X-ray (EDX) and X-ray photoelectron spectroscopy (XPS) analysis. HR-TEM images are confirmed that green synthesized BaCO3 NPs have spherical, triangular and uneven shapes. EDX analysis confirmed the presence of Ba, C and O. The peaks at 2θ of 19.45, 23.90, 24.29, 27.72, 33.71, 34.08, 34.60, 41.98, 42.95, 44.18, 44.85, and 46.78 corresponding to (110), (111), (021), (002), (200), (112), (130), (221), (041), (202), (132) and (113) showed that BaCO3 NPs average size was ~18.3 nm. SAED pattern confirmed that BaCO3 NPs are crystalline nature. BaCO3 NPs significantly inhibited cervical carcinoma cells, as evidenced by cytotoxicity assay. Immunofluorescence and fluorescence assays showed that BaCO3 NPs increased the expression and activity of caspase-3, an autocatalytic enzyme that promotes apoptosis. According to the results, green synthesis route has great potential for easy, rapid, inexpensive, eco-friendly and efficient development of novel multifunctional nanoparticles for the treatment of cancer. |
| File Format |
HTM / HTML |
| ISSN |
10111344 |
| Volume Number |
156 |
| e-ISSN |
18732682 |
| Journal |
Journal of Photochemistry and Photobiology B: Biology |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2016-03-01 |
| Publisher Place |
Switzerland |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Biology Antineoplastic Agents Pharmacology Barium Carbonates Nanoparticles Chemistry In Vitro Techniques Microscopy, Electron, Transmission Spectrometry, X-ray Emission Spectroscopy, Fourier Transform Infrared X-ray Diffraction Journal Article Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Radiology, Nuclear Medicine and Imaging Biophysics Radiological and Ultrasound Technology Radiation |
