NDLI: Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue.

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Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue.

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Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kubota, Takehiko Itagaki, Manami Hoshino, Chika Nagata, Masaki Morozumi, Toshiya Kobayashi, Tetsuo Takagi, Ritsuo Yoshie, Hiromasa
Description	Country affiliation: Japan Author Affiliation: Kubota T ( Division of Periodontology, Department of Oral Biological Science, Course for Oral Life Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. kubota@dent.niigata-u.ac.jp)
Abstract	BACKGROUND: The balance between the degradation and synthesis of extracellular matrix determines periodontal attachment levels and alveolar bone matrix concentration in periodontal diseases. Matrix metalloproteinases (MMPs) are known to degrade periodontal ligamental attachment and bone matrix proteins. The purpose of this study was to examine the effect of different expression levels of MMPs and their inhibitors, the tissue inhibitors of matrix metalloproteinases (TIMPs), in periodontitis. METHODS: Sixteen inflamed gingival tissue samples from subjects with generalized chronic periodontitis and 14 control tissue samples from systemically and periodontally healthy subjects were evaluated. The total RNA was extracted, and the transcript levels for MMP-1, -3, -9, and -13 and TIMP-1, -2, -3, and -4 relative to beta-actin were determined by quantitative real-time reverse transcription-polymerase chain reaction. RESULTS: Gene transcript levels for MMP-1 and TIMP-4 were significantly higher in periodontitis-affected gingival tissues (P <0.05). MMP-3, -9, and -13 and TIMP-1 mRNAs also were elevated in periodontitis; however, the difference was not statistically significant. TIMP-2 and -3 mRNA levels were similar in healthy and diseased gingivae. The ratios of MMP-1/TIMP-2 (P <0.01), MMP-3/TIMP-2 (P <0.05), MMP-9/TIMP-2 (P <0.05), and MMP-1/TIMP-3 (P <0.01) from periodontitis lesions were significantly higher than those in the control tissues. CONCLUSIONS: Upregulated MMP expression and an increased MMP/TIMP ratio indicate that a potential imbalance between degradation and synthesis of extracellular matrix persists in periodontitis-affected gingival tissues. This process may be responsible for increased tissue breakdown in periodontitis.
File Format	HTM / HTML
ISSN	00223492
Issue Number	1
Volume Number	79
e-ISSN	19433670
Journal	Journal of Periodontology
Language	English
Publisher	American Academy of Periodontology
Publisher Date	2008-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Dentistry Gingivitis Enzymology Matrix Metalloproteinases Analysis Periodontitis Tissue Inhibitor Of Metalloproteinases Actins Adolescent Adult Chronic Disease Female Gene Expression Regulation Genetics Gingiva Humans Male Matrix Metalloproteinase 1 Matrix Metalloproteinase 13 Matrix Metalloproteinase 3 Matrix Metalloproteinase 9 Reverse Transcriptase Polymerase Chain Reaction Tissue Inhibitor Of Metalloproteinase-1 Tissue Inhibitor Of Metalloproteinase-2 Tissue Inhibitor Of Metalloproteinase-3 Transcription, Genetic Up-regulation Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Periodontics

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