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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Goteiner, David Ashmen, Robert Lehrman, Neal Janal, Malvin N. Eskin, Barnet |
| Description | Country affiliation: United States Author Affiliation: Goteiner D ( Department of Periodontics, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA. drgoteiner@yahoo.com) |
| Abstract | BACKGROUND: The purpose of this study was to determine whether acute coronary syndrome (ACS) and angina patients have a greater prevalence of interleukin (IL)-1 polymorphism at the time of hospital admission than groups without ACS or angina. METHODS: A total of 106 patients hospitalized with ACS or angina were compared to a group of 1,959 individuals tested for susceptibility to periodontitis by profiling the IL-1 gene. Blood collected upon admission was analyzed by polymerase chain reaction amplification and gel electrophoresis to determine IL-1 polymorphism. A questionnaire was completed to assess home care and periodontal symptoms. Hospital and dental records were assessed for inclusion in the study, and dental records were analyzed for radiographic bone loss and dental history. RESULTS: ACS/angina patients with severe radiographic bone loss demonstrated an increase in IL-1-positive polymorphism (P = 0.06). If patients were > or =60 years of age, the prevalence of the positive gene was enriched (P = 0.009) with IL-1alpha+4845T increasing significantly (P = 0.015). CONCLUSIONS: For patients > or =60 years of age, there was a statistically significant correlation between ACS/angina and IL-1 polymorphism. Patients with ACS or angina were more likely to evidence a positive IL-1 polymorphism and severe periodontitis. |
| File Format | HTM / HTML |
| ISSN | 00223492 |
| Issue Number | 1 |
| Volume Number | 79 |
| e-ISSN | 19433670 |
| Journal | Journal of Periodontology |
| Language | English |
| Publisher | American Academy of Periodontology |
| Publisher Date | 2008-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Dentistry Acute Coronary Syndrome Genetics Angina Pectoris Interleukin-1 Periodontitis Polymorphism, Genetic Complications Age Factors Alveolar Bone Loss Chronic Disease Cytosine Dental Care Dentition Disease Susceptibility Epidemiologic Studies Gene Expression Profiling Hospitalization Humans Interleukin-1alpha Interleukin-1beta Middle Aged Patient Admission Pilot Projects Radiography Thymine Comparative Study Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Periodontics |
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