NDLI: The Periodontitis and Vascular Events (PAVE) pilot study: adverse events.

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The Periodontitis and Vascular Events (PAVE) pilot study: adverse events.

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The Periodontitis and Vascular Events (PAVE) pilot study: adverse events.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Beck, James D. Couper, David J. Falkner, Karen L. Graham, Susan P. Grossi, Sara G. Gunsolley, John C. Madden, Theresa Maupome, Gerardo Offenbacher, Steven Stewart, Dawn D. Trevisan, Maurizio Van Dyke, Thomas E. Genco, Robert J.
Description	Country affiliation: United States Author Affiliation: Beck JD ( Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. james_beck@unc.edu)
Abstract	BACKGROUND: During the last 15 years, a substantial number of population-based, clinical, laboratory, and animal studies have been published that reported findings on the relationship between periodontal disease and cardiovascular disease. The Periodontitis and Vascular Events (PAVE) pilot study was conducted to investigate the feasibility of a randomized secondary prevention trial to test whether treatment of periodontal disease reduces the risk for cardiovascular disease. This article describes the occurrence of adverse events during the pilot study. METHODS: The PAVE pilot study was a multicenter, randomized trial comparing periodontal therapy to community dental care. Baseline and follow-up clinic visits included a periodontal examination; blood, subgingival plaque, and crevicular fluid specimen collection; and medical and dental histories. Telephone follow-up contacts were scheduled to occur 3 months after randomization and every 6 months thereafter to assess adverse events or endpoints. RESULTS: Cardiovascular adverse events occurred with similar frequency (23 versus 24 [P = 0.85] in the community control and the treatment groups, respectively). There were 15 serious adverse events (SAEs) with a non-significantly higher percentage occurring in the community care group (6.6% versus 3.3%; P = 0.19). A time-to-event analysis of patterns of SAEs indicated that subjects in the periodontal therapy group tended to be less likely to experience an SAE over the entire 25 months of the study. CONCLUSION: For those individuals who remained in the study, it appears that provision of periodontal scaling and root planing treatment to individuals with heart disease resulted in a similar pattern of adverse events as seen in the community care group, which also received some treatment.
File Format	HTM / HTML
ISSN	00223492
Issue Number	1
Volume Number	79
e-ISSN	19433670
Journal	Journal of Periodontology
Language	English
Publisher	American Academy of Periodontology
Publisher Date	2008-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Dentistry Coronary Artery Disease Prevention & Control Periodontitis Abscess Etiology Community Health Services Community-acquired Infections Blood Complications Dental Care Dental Plaque Index Dental Scaling Depression Feasibility Studies Female Follow-up Studies Gingival Crevicular Fluid Chemistry Humans Hypertension Male Middle Aged Oral Hygiene Pilot Projects Pneumonia Root Planing Subgingival Curettage Tooth Diseases Treatment Outcome Comparative Study Journal Article Multicenter Study Randomized Controlled Trial Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Periodontics

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