NDLI: Do antibiotic prophylaxis and/or circumcision change periurethral uropathogen colonization and urinary tract infection rates in boys with VUR?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gücük, Adnan Burgu, Berk Gökçe, Ilker Mermerkaya, Murat Soygür, Tarkan
Description	Author Affiliation: Gücük A ( Department of Urology, Abant Izzet Baysal University Faculty of Medicine, Gölköy Kampusu, Bolu, Turkey. Electronic address: gucukadnan@hotmail.com.)
Abstract	BACKGROUND: To evaluate the effect of circumcision and/or antibiotic prophylaxis on periurethral flora and associated bacteriuria in male children with and without vesicoureteral reflux (VUR). PATIENTS AND METHODS: The study included 91 boys with low-grade VUR and 106 healthy boys (control) without VUR. The boys with VUR were randomized as antibiotic prophylaxis only and antibiotic prophylaxis plus circumcision. The boys without VUR were randomized as circumcision group and followed-up group without circumcision. Periurethral swab and urine cultures were obtained from the participants at the beginning of the study, and at 1st, 3rd, 6th, 9th, and 12th month. The groups were compared in terms of positive periurethral and urine cultures. RESULTS: The positive periurethral culture rate was significantly lower in the circumcised boys at all measurement times. The positive urine culture rate in the circumcised boys was lower than in the uncircumcised boys. Subgroup analysis based on age groups showed that age did not affect these statistical differences. CONCLUSION: Circumcision decreases colonization of periurethral bacterial pathogenic flora. In boys with low-grade VUR, circumcision plus antibiotic prophylaxis prevented recurrent and febrile urinary tract infections.
File Format	HTM / HTML
ISSN	14775131
Part	Pt B
Volume Number	9
e-ISSN	18734898
Journal	Journal of Pediatric Urology
Issue Number	6
Language	English
Publisher	Elsevier
Publisher Date	2013-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Urology Discipline Pediatrics Anti-bacterial Agents Therapeutic Use Circumcision, Male Urinary Tract Infections Drug Therapy Prevention & Control Vesico-ureteral Reflux Complications Bacteriuria Child, Preschool Combined Modality Therapy Follow-up Studies Humans Infant Male Prospective Studies Treatment Outcome Urethra Microbiology Surgery Comparative Study Journal Article Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Urology Pediatrics, Perinatology and Child Health

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Do antibiotic prophylaxis and/or circumcision change periurethral uropathogen colonization and urinary tract infection rates in boys with VUR?

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Do antibiotic prophylaxis and/or circumcision change periurethral uropathogen colonization and urinary tract infection rates in boys with VUR?