NDLI: Improved bioabsorbability of synthetic hydroxyapatite through partial dissolution-precipitation of its surface.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ding, Xianjun Takahata, Masahiko Akazawa, Toshiyuki Iwasaki, Norimasa Abe, Yuichiro Komatsu, Miki Murata, Masaru Ito, Manabu Abumi, Kuniyoshi Minami, Akio
Description	Country affiliation: Japan Author Affiliation: Ding X ( Department of Orthopedic Surgery, Graduate School of Medicine, Hokkaido University, Kita-15 Nishi-7, Kita-ku, Sapporo, 060-8638, Japan.)
Abstract	Even though synthetic hydroxyapatite (HAp) has a chemical composition similar to the mineral phase of bone, it is minimally absorbed and replaced by bone tissue. This could be because HAp is composed of compactly arranged apatite crystals with homogenously large grains. In this study, the surface and non-stoichiometry of the synthetic HAp crystals was modified by partial dissolution and precipitation (PDP) to improve bioabsorbability of HAp. In vitro cell culture demonstrated that more osteoclasts were activated on PDP-HAp compared with HAp. In vivo implantation using a rabbit bone defect model revealed that PDP-HAp was gradually degraded and was replaced by bone tissue. Consistent with the in vitro results, more osteoclasts were activated in PDP-HAp than in HAp, indicating that the former was absorbed through the stimulation of osteoclastic activity. These results suggest that the PDP technique may have clinical utility for modifying synthetic HAp for use as superior bone graft substitutes.
File Format	HTM / HTML
ISSN	09574530
Issue Number	5
Volume Number	22
e-ISSN	15734838
Journal	Journal of Materials Science: Materials in Medicine
Language	English
Publisher	Springer
Publisher Date	2011-05-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Biomedical Engineering Absorbable Implants Durapatite Chemistry Animals Bone Development Physiology Bone Marrow Cells Bone And Bones Injuries Cell Proliferation Female Gene Expression Regulation Mice Osteoblasts Pentostatin Rna, Messenger Genetics Metabolism Rabbits Surface Properties Journal Article
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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