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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dirican, Enver Kerem Ozgün, Osman Denizhan Akarsu, Süleyman Akin, Kadir Okhan Ercan, Ozge Ugurlu, Mukaddes Camsari, Cagri Kanyilmaz, Oya Kaya, Adnan Unsal, Ali |
| Description | Country affiliation: Turkey Author Affiliation: Dirican EK ( Embryology, MAYA Center for Assisted Reproductive Technologies, Ankara, Turkey. kerem@dirican.tr.tc) |
| Abstract | PURPOSE: Magnetic activated cell sorting (MACS) eliminates apoptotic spermatozoa based on the presence of externalized phosphatidylserine residues. We evaluated the outcome of male fertility treatment when intracytoplasmic sperm injection (ICSI) into human oocytes was performed with non-apoptotic MACS-selected spermatozoa. METHODS: 196 couples were treated by ICSI following spermatozoa preparation by MACS (study group; 122 couples) or density gradient centrifugation (DGC) (control group; 74 couples). Fertilization, cleavage, pregnancy, and implantation rates were analyzed. RESULTS: The percentage of sperm with normal morphology after MACS selection was improved. Cleavage and pregnancy rates were higher, respectively, in the study group than in control. A slightly higher implantation rate was also observed in the study group. CONCLUSIONS: MACS selection of human spermatozoa increased cleavage and pregnancy rates in oligoasthenozoospermic ART cases. This novel method for selecting non-apoptotic spermatozoa for ICSI is safe and reliable, and may improve the assisted reproduction outcome. |
| File Format | HTM / HTML |
| ISSN | 10580468 |
| e-ISSN | 15737330 |
| DOI | 10.1007/s10815-008-9250-1 |
| Journal | Journal of Assisted Reproduction and Genetics |
| Issue Number | 8 |
| Volume Number | 25 |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2008-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Discipline Reproductive Medicine Discipline Genectics Cell Separation Centrifugation, Density Gradient Magnetics Spermatozoa Pathology Apoptosis Fertility Fertilization Phosphatidylserines Chemistry Pregnancy Pregnancy Rate Reproductive Techniques, Assisted Semen Metabolism |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Developmental Biology Reproductive Medicine Genetics (clinical) Obstetrics and Gynecology |
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