NDLI: Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study.

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Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kurzawa, Rafal Ciepiela, Przemyslaw Baczkowski, Tomasz Safranow, Krzysztof Brelik, Pawel
Description	Country affiliation: Poland Author Affiliation: Kurzawa R ( Department of Reproductive Medicine and Gynecology, Pomeranian Medical University, Szczecin-Police, Poland.)
Abstract	PURPOSE: Embryological and clinical efficacy of gonadotropin-releasing hormone (GnRH) antagonist and agonist stimulation protocols in non-obese women with polycystic ovarian syndrome (PCOS) were compared. METHODS: A prospective randomized study. SETTING: Medical University Hospital. PATIENTS: 70 infertile PCOS patients; 33 in GnRH antagonist and 37 in GnRH agonist group. RESULTS: Similar mature metaphase II oocyte rate (76% vs. 76%) was observed in both protocols. Optimal pronuclear morphology zygotes dominated in both groups (64% vs. 66%). Transferred embryo quality did not differ in both protocols. No significant differences between both protocols were found in delivery rate (p = 0.481), pregnancy rate (p = 0.810), multiple pregnancy rate (p = 0.501), miscarriage rate (p = 0.154), fertilization rate (p = 0.388) and implantation rate (p = 1.000). Duration of stimulation and total follicle-stimulating hormone (FSH) dose were significantly lower in GnRH antagonist protocol (p = 0.0005). CONCLUSIONS: GnRH antagonist and agonist protocols in non-obese PCOS patients yield similar embryological and clinical outcomes. Shorter duration of treatment and lower FSH requirement in GnRH antagonist group may be financially beneficial and therefore attractive for patients.
File Format	HTM / HTML
ISSN	10580468
e-ISSN	15737330
DOI	10.1007/s10815-008-9249-7
Journal	Journal of Assisted Reproduction and Genetics
Issue Number	8
Volume Number	25
Language	English
Publisher	Springer
Publisher Date	2008-08-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Reproductive Medicine Discipline Genectics Fertilization In Vitro Gonadotropin-releasing Hormone Agonists Antagonists & Inhibitors Therapeutic Use Polycystic Ovary Syndrome Drug Therapy Abortion, Spontaneous Fertilization Obesity Complications Oocytes Cytology Pregnancy Pregnancy Rate Prospective Studies Spermatozoa Metabolism Comparative Study Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology Reproductive Medicine Genetics (clinical) Obstetrics and Gynecology

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Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study

Ovulation triggering with GnRH agonist vs. hCG in the same egg donor population undergoing donor oocyte cycles with GnRH antagonist: a prospective randomized cross-over trial.

Gonadotropin-releasing hormone (GnRH)-antagonist versus GnRH-agonist in ovarian stimulation of poor responders undergoing IVF.

IVF/ICSI outcomes between cycles with luteal estradiol (E2) pre-treatment before GnRH antagonist protocol and standard long GnRH agonist protocol: a prospective and randomized study.

GnRH antagonist versus long GnRH agonist protocol in poor IVF responders: a randomized clinical trial.

Early pregnancy loss rates were different among singleton gestations conceived by ICSI using GnRH agonist and antagonist.

Luteal phase oestradiol administration in ovarian stimulation cycles with GnRH antagonist is comparable to the GnRH agonist (long) protocol.

Comparisons of GnRH antagonist versus GnRH agonist protocol in poor ovarian responders undergoing IVF.

Comparison of gonadotropin-releasing hormone agonist with GnRH antagonist in polycystic ovary syndrome patients undergoing in vitro fertilization cycle: Retrospective analysis from a tertiary center and review of literature

Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study.

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Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study

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