NDLI: CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women.

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CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ye, Yi Cheng, Xiao Luo, Hai-Bo Liu, Li Li, Ying-Bi Hou, Yi-Ping
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Ye Y ( Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Sichuan, China.)
Abstract	PURPOSE: The aim of the study was to evaluate the association of CYP1A1 and CYP1B1 polymorphisms with uterine leiomyoma in Chinese women. METHODS: We investigated 100 women with clinically diagnosed uterine leiomyoma and 110 healthy normal subjects from Chinese women. The genetic distribution of two CYP1A1 polymorphisms at MspI, Ile462Val and four CYP1B1 polymorphisms at Arg48Gly, Ala119Ser, Leu432Val, Asp449Asp were analyzed by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing method. RESULTS: All the SNPs showed polymorphisms in Chinese women. The genotype A/G and the allele G on Ile462Val was significantly different between uterine leiomyoma patients and controls (P < 0.05). CONCLUSION: These results suggest that the genotype of CYP1A1 Ile462Val was associated with the increased risk of uterine leiomyomas in Chinese women.
File Format	HTM / HTML
ISSN	10580468
e-ISSN	15737330
DOI	10.1007/s10815-008-9246-x
Journal	Journal of Assisted Reproduction and Genetics
Issue Number	8
Volume Number	25
Language	English
Publisher	Springer
Publisher Date	2008-08-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Reproductive Medicine Discipline Genectics Cytochrome P-450 Cyp1a1 Genetics Physiology Cytochrome P-450 Enzyme System Leiomyoma Ethnology Polymorphism, Genetic Uterine Neoplasms Alleles Aryl Hydrocarbon Hydroxylases Cytochrome P-450 Cyp1b1 Gene Frequency Genotype Models, Statistical Polymorphism, Restriction Fragment Length Sequence Analysis, Dna Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology Reproductive Medicine Genetics (clinical) Obstetrics and Gynecology

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