NDLI: Primary localized histoplasmosis with lesions restricted to the mouth in a Chinese HIV-negative patient.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ge, Lan Zhou, Cunjian Song, Zhiqiang Zhang, Yin Wang, Li Zhong, Baiyu Hao, Fei
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Ge L ( Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.)
Abstract	Histoplasmosis is a deep mycosis caused by Histoplasma capsulatum, which is endemic in many areas of the world but is relatively rare in China. Although the majority of cases present as a mild to moderate flu-like disease requiring only supportive therapy, approximately 1% of patients experience more serious pulmonary and extrapulmonary disease, which can be life-threatening if diagnosis is delayed or the treatment is not initiated rapidly. Definitive diagnosis is usually made by a combination of culture, detection of the organism in tissues, measurement of antibodies, and detection of antigen. We present the case of a 51-year-old patient who presented with histoplasmosis only, with several ulcerated lesions in the oral cavity and without HIV infection, who did not show any detectable signs and symptoms of systemic disease or extra-oral manifestations. Histopathological analysis indicated a chronic inflammatory process with granulomas with yeast-like organisms. Isolation of H. capsulatum and molecular identification provided the definitive diagnosis. Treatment with oral itraconazole led to remission of the oral lesions. This is the first Chinese case report of localized histoplasmosis with lesions restricted to the mouth in an HIV-negative patient.
File Format	HTM / HTML
ISSN	12019712
e-ISSN	18783511
Journal	International Journal of Infectious Diseases
Issue Number	Suppl 3
Volume Number	14
Language	English
Publisher	Elsevier
Publisher Date	2010-09-01
Publisher Place	Canada
Access Restriction	Open
Subject Keyword	Discipline Communicable Diseases Histoplasmosis Diagnosis Mouth Diseases Antifungal Agents Therapeutic Use Dna Primers Genetics Dna, Fungal Hiv Seronegativity Histoplasma Isolation & Purification Drug Therapy Microbiology Itraconazole Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Case study Article
Subject	Infectious Diseases Microbiology (medical)

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