NDLI: Emerging invasive zygomycosis in a tertiary care center: epidemiology and associated risk factors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ambrosioni, Juan Bouchuiguir-Wafa, Kalthum Garbino, Jorge
Spatial Coverage	Switzerland
Description	Country affiliation: Switzerland Author Affiliation: Ambrosioni J ( Division of Infectious Diseases, University of Geneva Hospitals and Faculty of Medicine, 4 Rue Gabrielle Perret-Gentil, Geneva 14, Switzerland.)
Abstract	OBJECTIVES: Invasive zygomycosis is a rare fungal opportunistic disease with a high morbidity and mortality rate, predominantly affecting immunosuppressed patients. Presented herein is our investigation of the epidemiological factors associated with an increasing incidence of the disease at the University of Geneva Hospitals, Geneva, Switzerland, over the past five years. METHODS: This was a retrospective study of the clinical charts and microbiology records of patients with a positive culture for zygomycetes, to evaluate predisposing factors and epidemiological characteristics. RESULTS: Three of 19 proven/probable invasive infections were diagnosed during 1989-2003, and 16 during 2003-2008. While the number of positive isolates for zygomycetes remained mainly stable, the ratio between invasive infections and colonized patients increased after the introduction of voriconazole and caspofungin in 2003 at our institution (p<0.001). All cases were unrelated and no nosocomial source of exposure or seasonal aggregation was identified. The increase in cases was coincident with an incremented use of voriconazole and caspofungin, and with an increased number of immunosuppressed patients, especially allogeneic bone marrow transplant recipients. CONCLUSIONS: Invasive zygomycosis is an emerging infection at our center and is probably related to an increase in immunosuppressed patients and the wide use of newer antifungals. Changes in antifungal drug prophylaxis and treatment prescription may help to control this emergence.
File Format	HTM / HTML
ISSN	12019712
e-ISSN	18783511
Journal	International Journal of Infectious Diseases
Issue Number	Suppl 3
Volume Number	14
Language	English
Publisher	Elsevier
Publisher Date	2010-09-01
Publisher Place	Canada
Access Restriction	Open
Subject Keyword	Discipline Communicable Diseases Communicable Diseases, Emerging Epidemiology Zygomycosis Adolescent Antifungal Agents Therapeutic Use Bone Marrow Transplantation Adverse Effects Drug Therapy Etiology Microbiology Hematologic Neoplasms Complications Hospitals, Teaching Retrospective Studies Switzerland
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Microbiology (medical)

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