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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ciruela, Pilar Soldevila, Núria Selva, Laura Hernández, Sergi Garcia-Garcia, Juan Jose Moraga, Fernando de Sevilla, Mariona F. Codina, Gemma Planes, Ana Maria Esteva, Cristina Coll, Francis Cardeñosa, Neus Jordan, Iolanda Batalla, Joan Salleras, Luis Muñoz-Almagro, Carmen Domínguez, Angela |
| Spatial Coverage | Spain |
| Description | Country affiliation: Spain Author Affiliation: Ciruela P ( Public Health Agency of Catalonia) |
| Abstract | The aim of this study was to investigate risk factors for the most common serotypes of invasive pneumococcal disease (IPD). A total of 293 IPD cases were analyzed in children aged 3-59 mo in a community with intermediate vaccination coverage with the 7-valent pneumococcal vaccine (PCV7). IPD cases were reviewed during 2007-2009 in two pediatric hospitals in Catalonia (Spain). A multivariate analysis using unconditional logistic regression was performed to estimate the adjusted odds ratio. PCV7 coverage was 45.4%. Pneumonia with empyema (64.5%) was the most frequent clinical manifestation. The most common serotypes were: serotype 1 (21.2%), 19A (16.0%), 3 (12.6%) and 7F/A (6.8%). 70.0% of serotypes found were included in the 13-valent conjugate vaccine (PCV13), 39.2% in the 10-valent conjugate vaccine and 8.1% in the PCV7. PCV7 was protective in IPD cases due to PCV7-serotypes (aOR: 0.15, 95% CI:0.04-0.55). Serotype 1 was positively associated with attending day care or school (aOR: 3.55, 95% CI: 1.21-10.38) and age 24-59 mo (aOR: 7.70, 95% CI:2.70-21.98). Serotype 19A was positively associated with respiratory infection in the previous month (aOR: 2.26, 95% CI: 1.03-4.94), non-penicillin susceptible IPD (aOR: 1.89, 95% CI:1.13-3.16) and negatively associated with age 24-59 mo (aOR: 0.19, 95% CI:0.09-0.41). Serotype 3 was positively associated with vaccination (aOR: 4.87, 95% CI:2.05-11.59). No factors were associated with serotype 7F/A. Vaccination with pneumococcal vaccines including more serotypes may reduce the risk of disease in our setting. |
| File Format | HTM / HTML |
| ISSN | 21645515 |
| e-ISSN | 2164554X |
| Journal | Human Vaccines & Immunotherapeutics |
| Issue Number | 3 |
| Volume Number | 9 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2013-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Immunology Discipline Therapeutics Pneumococcal Infections Epidemiology Microbiology Streptococcus Pneumoniae Classification Child, Preschool Infant Pneumococcal Vaccines Immunology Risk Assessment Risk Factors Serogroup Spain Isolation & Purification Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology Pharmacology |
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