NDLI: Targeted therapy for thymic epithelial tumors: a new horizon? Review of the literature and two cases reports.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Simonelli, Matteo Zucali, Paolo A. Suter, Matteo B. Lorenzi, Elena Rubino, Luca Fatuzzo, Giuseppe Alloisio, Marco Santoro, Armando
Description	Country affiliation: Italy Author Affiliation: Simonelli M ( Humanitas Cancer Center, Oncology & Hematology Unit, Istituto Clinico Humanitas IRCCS, 20089 Rozzano MI, Italy.)
Abstract	Surgical resection remains the cornerstone of therapy for early-stage thymic epithelial tumors (TETs), while in advanced or recurrent forms, a multimodality approach incorporating radiation and chemotherapy is required. Given the absence of effective treatment options for metastatic/refractory TETs and the poor related prognosis, there is a compelling need to identify promising 'drugable' molecular targets. Initial reports of activity from targeted agents in TETs derived from anecdotal cases have been often associated with specific activating mutations. Only in recent years, several agents have been formally investigated into prospective clinical trials, with varying success rates. We reviewed the literature on targeted therapy in TETs along with two cases of thymoma achieving striking responses to sorafenib in combination with lapatinib.
File Format	HTM / HTML
ISSN	14796694
Issue Number	8
Volume Number	11
e-ISSN	17448301
Journal	Future Oncology
Language	English
Publisher	Future Medicine Ltd.
Publisher Date	2015-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Antineoplastic Combined Chemotherapy Protocols Therapeutic Use Molecular Targeted Therapy Neoplasms, Glandular And Epithelial Drug Therapy Pleural Neoplasms Protein Kinase Inhibitors Thymus Neoplasms Aged Female Histone Deacetylase Inhibitors Humans Pathology Surgery Niacinamide Administration & Dosage Analogs & Derivatives Phenylurea Compounds Secondary Proto-oncogene Proteins C-kit Antagonists & Inhibitors Quinazolines Receptor, Epidermal Growth Factor Receptors, Somatomedin Tor Serine-threonine Kinases Young Adult Case Reports Journal Article Review
Content Type	Text
Resource Type	Case study Article
Subject	Cancer Research Oncology

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