NDLI: Pazopanib for the treatment of renal cell carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Welsh, Sarah J. Fife, Kate
Description	Country affiliation: United kingdom Author Affiliation: Welsh SJ ( Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.)
Abstract	The incidence and mortality from renal cell cancer (RCC) is increasing. RCC tumors are particularly vascular in nature as a result of disruption of the VHL gene and/or its upstream pathway leading to upregulation of the hypoxia-inducible factor transcription factor. The hypoxia-inducible factor pathway drives angiogenesis by upregulating VEGF and bFGF, amongst other proangiogenic downstream target genes. Therapies which target angiogenesis have been successful in treating metastatic RCC (mRCC) and the receptor tyrosine kinase inhibitor, pazopanib, is licensed for first line treatment of mRCC. This review details the past, current and future roles of pazopanib in the treatment of mRCC.
File Format	HTM / HTML
ISSN	14796694
Issue Number	8
Volume Number	11
e-ISSN	17448301
Journal	Future Oncology
Language	English
Publisher	Future Medicine Ltd.
Publisher Date	2015-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Angiogenesis Inhibitors Therapeutic Use Carcinoma, Renal Cell Drug Therapy Kidney Neoplasms Pyrimidines Sulfonamides Animals Tumor Markers, Biological Secondary Drug-induced Liver Injury Etiology Clinical Trials As Topic Drug Resistance, Neoplasm Humans Pathology Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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