NDLI: Use of gemcitabine-platinum in Indian patients with advanced gall bladder cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sirohi, Bhawna Rastogi, Sameer Singh, Ashish Sheth, Vipul Dawood, Shaheenah Talole, Sanjay Ramadwar, Mukta Kulkarni, Suyash Shrikhande, Shailesh V.
Spatial Coverage	India
Description	Country affiliation: India Author Affiliation: Sirohi B ( Department of Medical Oncology, Tata Memorial Centre, Parel, Mumbai, India.)
Abstract	BACKGROUND: Gemcitabine-platinum (Gem-P) is the current standard for patients with advanced gall bladder cancer. MATERIALS & METHODS: This is retrospective analysis of a prospectively maintained database of 210 patients with advanced gall bladder cancer treated with Gem-P between January 2012 and September 2013. RESULTS: Median age was 53 years, 65.2% females. In total,158 patients had metastatic and 52 had locoregional disease. Median number of cycles was 5 (1-12). At a median follow-up of 10 months, median overall survival/progression-free survival was 10/5 months, respectively. On multivariate analysis, patients who underwent prior surgery for primary and locoregional disease had a significantly better progression-free survival and those with locoregional disease had a significantly better overall survival. A total of 45.7% received second-line chemotherapy. CONCLUSION: Use of Gem-P in Indian patients leads to slightly worse outcomes suggesting an aggressive biology.
File Format	HTM / HTML
ISSN	14796694
Issue Number	8
Volume Number	11
e-ISSN	17448301
Journal	Future Oncology
Language	English
Publisher	Future Medicine Ltd.
Publisher Date	2015-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Antineoplastic Combined Chemotherapy Protocols Therapeutic Use Gallbladder Neoplasms Drug Therapy Pathology Palliative Care Adult Aged Administration & Dosage Adverse Effects Camptothecin Analogs & Derivatives Cisplatin Deoxycytidine Disease-free Survival Female Fluorouracil Surgery Humans India Insecticide-treated Bednets Male Middle Aged Organoplatinum Compounds Retrospective Studies Survival Rate Treatment Outcome Journal Article
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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