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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Viezeliene, Dale Jansen, Eugene Rodovicius, Hiliaras Kasauskas, Arturas Ivanov, Leonid |
| Description | Country affiliation: Lithuania Author Affiliation: Viezeliene D ( Department of Biochemistry, Kaunas University of Medicine, Mickeviciaus 9, LT-44307 Kaunas, Lithuania. daleveze@med.kmu.lt) |
| Abstract | The aim of the study was to evaluate possible protective effects of selenium (Se) against systemic aluminium (Al) toxicity and the redox status of mouse liver after short-term (16 h) exposure to Al in vivo. BALB/c mice were injected i.p. with AlCl(3) (25mg Al(3+) per kg of body mass) or/and Na(2)SeO(3) (1.25mg Se per kg of body mass). The 4-fold increased activity of ALT in serum showed systemic hepatotoxicity that Se could not prevent by competitive mechanisms. The protective effects of Se could only be observed on intracellular oxidative stress events as determined by glutathione status. Exposure to Al leads to the decrease in the total glutathione (GSH(tot)) and GSH/GSSG redox ratio to about 50% of the control. Upon co-exposure to Se+Al, the concentration of GSH(tot) and the redox ratio was restored to the control values. Our results indicate that Se did not have a protective effect on Al-linked liver toxicity, but did ameliorate intracellular oxidative stress processes mediated by glutathione. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 2 |
| Volume Number | 31 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Aluminum Toxicity Antioxidants Pharmacology Liver Drug Effects Oxidative Stress Selenium Alanine Transaminase Blood Animals Glutathione Metabolism Glutathione Disulfide Male Mice Mice, Inbred Balb C Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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