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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Xu, Xiao-lin Pan, Chen Hu, Jin-xia Liu, Xiang-tong Li, Yan-fang Wang, Hui Chen, Yin-bao Dong, Hong-yan Dai, Ti-jun Xu, Li-chun |
| Description | Country affiliation: China Author Affiliation: Xu XL ( School of Public Health, Xuzhou Medical College, 84 West Huai-hai Road, Xuzhou, Jiangsu 221002, China.) |
| Abstract | The 15-day intact adult male assay was used to evaluate effects of isoflurane on the testes and sexual hormones. Forty adult male Sprague-Dawley rats were divided into five groups exposed to air containing 0, 50, 300, 1800 or 10,800 ppm isoflurane. After the treatments, serum was collected for the hormones assay. The right testis was to be used for daily sperm production. The left testis was processed for histopathology and electron microscopy observation. Daily sperm productions were significantly decreased at doses of 300, 1800 and 10,800 ppm. Impaired seminiferous tubules were noted at doses of 300, 1800 and 10,800 ppm. Ultrastructural changes included nucleus agglutination of spermatocytes, big lipid drops and autophagosome in cytoplasm. The serum follicle-stimulating hormone and testosterone concentrations reduced significantly at doses of 1800 and 10,800 ppm. Isoflurane induced impairments of seminiferous tubules and spermatogenesis. The testicular damages caused by isoflurane can be related to the imbalances in the sexual hormones. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 34 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Anesthetics, Inhalation Toxicity Inhalation Exposure Adverse Effects Isoflurane Spermatogenesis Drug Effects Administration & Dosage Animals Follicle Stimulating Hormone Blood Male Rats Rats, Sprague-dawley Seminiferous Tubules Sperm Count Spermatozoa Testis Pathology Ultrastructure Testosterone Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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