NDLI: Interaction of triphenyltin and an agonist of retinoid X receptor (LGD1069) in embryos of Xenopus tropicalis.

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Interaction of triphenyltin and an agonist of retinoid X receptor (LGD1069) in embryos of Xenopus tropicalis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shi, Huahong Zhang, Xiaoli Yu, Lin Yuan, Jing Sun, Zhi
Description	Country affiliation: China Author Affiliation: Shi H ( State Key Laboratory of Estuarine and Coastal Research, East China Normal University, Shanghai 200062, China. hhshi@des.ecnu.edu.cn)
Abstract	Xenopus tropicalis embryos were exposed for 48 h to mixtures of triphenyltin and LGD1069 (an agonist of the retinoid X receptor). The index of fin deficiency (IFD) of the embryos increased in the triphenyltin-treated groups, and the index of axis deficiency (IAD) increased in LGD1069-treated groups in a concentration-dependent manner. When embryos were exposed to mixtures of 5µgSn/L triphenyltin and 1-30 µg/L LGD1069, IFD decreased from 2.9 to 0.6 and IAD increased from 0.1 to 2.4 with increasing LGD1069 concentrations. Conversely, when embryos were exposed to mixtures of 15 µg/L LGD1069 and 1-10 µg Sn/L triphenyltin, IFD increased from 0.1 to 3.0 with increasing triphenyltin concentrations. Co-exposure induced some new phenotypes, such as posteriorized anus. These results suggest that LGD1069 suppressed the teratogenicity of triphenyltin and that the retinoid X receptor was involved in triphenyltin-induced teratogenicity. Histological observations indicate that co-exposure inhibited the invagination of the yolk plug.
File Format	HTM / HTML
ISSN	13826689
Issue Number	3
Volume Number	34
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2012-11-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Organotin Compounds Toxicity Retinoid X Receptors Agonists Water Pollutants, Chemical Abnormalities, Drug-induced Animals Embryo, Nonmammalian Abnormalities Drug Effects Pathology Physiology Endocrine Disruptors Metabolism Teratogens Xenopus Embryology Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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Stage-specific malformations and phenotypic changes induced in embryos of amphibian (Xenopus tropicalis) by triphenyltin.

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Stage-specific malformations and phenotypic changes induced in embryos of amphibian (Xenopus tropicalis) by triphenyltin.

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