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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sáez, M. I. García-Mesa, S. Casas, J. J. Guil-Guerrero, J. L. Venegas-Venegas, C. E. Morales, A. E. Suárez, M. D. |
| Description | Country affiliation: Spain Author Affiliation: Sáez MI ( GI PAI Ecología Acuática y Acuicultura, Campus de Excelencia Internacional Agroalimentario (ceiA3), Universidad de Almería, Almería, Spain.) |
| Abstract | The aim of the current research was to assess the possible influence of copper sulphate contamination on the antioxidant enzymatic defenses and lipid peroxidation (LPO) in the mosquitofish (Gambusia holbrooki). Quadruplicated lots of this fish were exposed to three increasing sub-lethal concentrations of Cu (0.10; 0.17 and 0.25mgCu/L) and a control without Cu for 20 days. Previous to laboratory acclimation, 8 fish were taken to define the initial population. At the end of the trials, 12 fish/sex/treatment were sampled for the determination of levels of copper in gills, metallothioneins (MTs) content, total lipids, fatty acids profiles and antioxidant enzymatic activity, as well as lipid peroxidation. Most of the antioxidant enzymatic defenses assayed were not activated and lipid peroxidation decreased significantly in fish exposed to any concentration of copper applied. This leads us to presume the existence of a protective mechanism against peroxidation other than the enzymatic antioxidant defense, which could be related to the observed increase of copper content in the gills. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Volume Number | 36 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Copper Sulfate Toxicity Cyprinodontiformes Metabolism Water Pollutants, Chemical Animals Catalase Pharmacokinetics Female Fish Proteins Gills Glutathione Peroxidase Glutathione Reductase Glutathione Transferase Lipid Metabolism Drug Effects Lipid Peroxidation Male Metallothionein Superoxide Dismutase Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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