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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Naik, Prashantha Rozman, Hj Din Bhat, Rajeev |
| Description | Country affiliation: India Author Affiliation: Naik P ( Department of Biosciences, Mangalore University, Mangalagangothri 574 199, India.) |
| Abstract | Black liquor waste (BLW), a major by-product of palm oil extraction process contains lignin as one of the constituents. Lignin isolated from BLW was evaluated for antioxidant and genoprotective properties and was compared with the commercial lignin for overall efficacy. Antioxidant compounds (phenolics and tannins) and antioxidant activities (phosphomolybdenum assay, ABTS(+) and FRAP assays) of lignin isolated from BLW were compared with commercial lignin. Bone marrow micronucleus (MN) test was employed for evaluating the dose-yield protective effect against cyclophosphamide (CP, 50mg/kg b.w.) induced genotoxicity in mouse. Results revealed isolated lignin to exhibit rich antioxidant activities. A decrease in MN frequency and recovery of P/N ratio (P: polychromatic erythrocytes, N: normochromatic erhythocytes) indicated protective effects of lignin against cyclophosphamide induced genotoxicity and cytotoxicity. The efficacy of BLW-derived lignin as an antioxidant and genoprotective agent was comparable to commercial lignin. Results on lignin isolated from BLW are envisaged to find potential applications in food and/or pharmaceutical industries. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Volume Number | 36 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Antimutagenic Agents Pharmacology Industrial Waste Lignin Micronuclei, Chromosome-defective Drug Effects Plant Oils Animals Isolation & Purification Bone Marrow Cells Cells, Cultured Cyclophosphamide Female Food-processing Industry Male Mice Chemically Induced Micronucleus Tests Mutagens Phenols Tannins Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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