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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rivero-Wendt, Carla Letícia Gediel Oliveira, Rhaul Monteiro, Marta Sofia Domingues, Inês Soares, Amadeu Mortágua Velho Maia Grisolia, Cesar Koppe |
| Description | Author Affiliation: Rivero-Wendt CL ( Departament of Biology, University Anhanguera-Uniderp, Campus Agrárias, R. Alexandre Herculano, 1400, Taquaral Bosque, CEP 79035-470 Campo Grande, MS, Brazil); Oliveira R ( Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, Asa Norte, CEP 70910-900 Brasília, DF, Brazil. Electronic address: rhaul.oliveira@gmail.com.); Monteiro MS ( Department of Biology & CESAM, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal. Electronic address: mmonteiro@ua.pt.); Domingues I ( Department of Biology & CESAM, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal. Electronic address: inesd@ua.pt.); Soares AM ( Department of Biology & CESAM, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal); Grisolia CK ( Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, Asa Norte, CEP 70910-900 Brasília, DF, Brazil. Electronic address: grisolia@unb.br.) |
| Abstract | The synthetic androgen 17 -methyltestosterone is widely used in fish aquaculture for sex reversion of female individuals. Little is known about the amount of MT residues reaching the aquatic environment and further impacts in non-target organisms, including fish early-life stages. Thus, in this work, zebrafish embryos were exposed to two forms of 17 -methyltestosterone: the pure compound (MT) and a formulation commonly used in Brazil (cMT). For MT, a 96h-LC50 of 10.09mg/l was calculated. MT also affected embryo development inducing tail malformations, edemas, abnormal development of the head, and hatching delay. At biochemical level MT inhibited vitellogenin (VTG) and inhibited cholinesterase and lactate dehydrogenase. cMT elicited similar patterns of toxicity as the pure compound (MT). Effects reported in this study suggest a potential environmental risk of MT, especially since the VTG effects occurred at environmental relevant concentrations (0.004mg/l). |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Journal | Environmental Toxicology and Pharmacology |
| Volume Number | 44 |
| e-ISSN | 18727077 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-06-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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