NDLI: Fatty acid composition in serum correlates with that in the liver and non-alcoholic fatty liver disease activity scores in mice fed a high-fat diet.

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Fatty acid composition in serum correlates with that in the liver and non-alcoholic fatty liver disease activity scores in mice fed a high-fat diet.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Xing-He Li, Chun-Yan Muhammad, Ishfaq Zhang, Xiu-Ying
Description	Author Affiliation: Wang XH ( Faculty of Basic Veterinary Science, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China. Electronic address: wangxinghe1987@163.com.); Li CY ( Faculty of Basic Veterinary Science, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China. Electronic address: ar1228@sina.com.); Muhammad I ( Faculty of Basic Veterinary Science, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China. Electronic address: ishfaqmuhammad03@gmail.com.); Zhang XY ( Faculty of Basic Veterinary Science, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China. Electronic address: zhangxiuying@neau.edu.cn.)
Abstract	In this study, we investigated the correlation between the serum fatty acid composition and hepatic steatosis, inflammation, hepatocellular ballooning scores, and liver fatty acids composition in mice fed a high-fat diet. Livers were collected for non-alcoholic fatty liver disease score analysis. Fatty acid compositions were analysed by gas chromatography. Correlations were determined by Pearson correlation coefficient. Exposed to a high-fat diet, mice developed fatty liver disease with varying severity without fibrosis. The serum fatty acid variation became more severe with prolonged exposure to a high-fat diet. This variation also correlated significantly with the variation in livers, with the types of fatty acids corresponding to liver steatosis, inflammation, and hepatocellular ballooning scores. Results of this study lead to the following hypothesis: the extent of serum fatty acid variation may be a preliminary biomarker of fatty liver disease caused by high-fat intake.
File Format	HTM / HTML
ISSN	13826689
Journal	Environmental Toxicology and Pharmacology
Volume Number	44
e-ISSN	18727077
Language	English
Publisher	Elsevier
Publisher Date	2016-06-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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