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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | da Silva Faria, Marcia C. Santos, Neife A. G. Dos Carvalho Rodrigues, Maria A. Rodrigues, Jairo Lisboa Barbosa Junior, Fernando Santos, Antonio Cardozo Dos |
| Description | Country affiliation: Brazil Author Affiliation: da Silva Faria MC ( Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto - USP, 14040-903 Ribeirão Preto, SP, Brazil.); Santos NA ( Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto - USP, 14040-903 Ribeirão Preto, SP, Brazil.); Carvalho Rodrigues MA ( Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto - USP, 14040-903 Ribeirão Preto, SP, Brazil.); Rodrigues JL ( Instituto de Ciência e Tecnologia do Mucuri, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni, MG, Brazil.); Barbosa Junior F ( Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto - USP, 14040-903 Ribeirão Preto, SP, Brazil.); Santos AC ( Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto - USP, 14040-903 Ribeirão Preto, SP, Brazil. Electronic address: acsantos@fcfrp.usp.br.) |
| Abstract | Both types of diabetes are associated with higher incidence of some types of cancer. Treating cancer in diabetic patients without aggravating diabetes-related complications is a challenge for clinicians. Additionally, little is known about how diabetes affects the treatment of cancer. One of the most effective chemotherapeutic drugs is cisplatin, which is nephrotoxic. Studies suggest that diabetes acts as a protective factor against the nephrotoxicity of cisplatin, but the mechanisms involved have not been elucidated yet. This renal protection has been attributed to decreased accumulation of cisplatin in the kidneys, which could be associated with deficient active transport of proximal tubular cells or to pharmacokinetic alterations caused by diabetes. However, it is uncertain if diabetes also compromises the antitumor activity of cisplatin. To address this issue, we developed a mouse model bearing cisplatin-induced nephrotoxicity, Sarcoma 180 and streptozotocin-induced diabetes. Four groups of treatment were defined: (i) control, (ii) diabetic, (iii) cisplatin and (iv) diabetic treated with cisplatin. The following parameters were evaluated: renal function, oxidative stress, apoptosis, renal histopathology, tumor remission, survival rate, genotoxicity and platinum concentration in tumor and several organs. Results indicate that diabetes protects against the renal damage induced by cisplatin, while also compromises its antitumor effectiveness. This is the first study to demonstrate this effect. |
| File Format | HTM / HTML |
| ISSN | 00092797 |
| Volume Number | 229 |
| e-ISSN | 18727786 |
| Journal | Chemico-Biological Interactions |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-03-05 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Discipline Pharmacology Antineoplastic Agents Pharmacokinetics Therapeutic Use Cisplatin Diabetes Mellitus, Experimental Complications Kidney Diseases Chemically Induced Sarcoma 180 Drug Therapy Animals Toxicity Apoptosis Drug Effects Cell Line, Tumor Metabolism Pathology Kidney Male Mice Oxidative Stress Tissue Distribution Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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