| Author |
Silva, Renan O. Damasceno, Samara R. B. Silva, Irismara S. Silva, Valdelânia G. Brito, Camila F. C. Teixeira, Antônio Éder A. Nunes, Geandra B. L. Camara, Celso A. Filho, José Maria B. Gutierrez, Stanley J. C. Ribeiro, Ronaldo A. Souza, Marcellus H. L. P. Barbosa, André L. R. Freitas, Rivelilson M. Medeiros, Jand Venes R. |
| Description |
Country affiliation: Brazil Author Affiliation: Silva RO ( Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.); Damasceno SR ( Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.); Silva IS ( Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil.); Silva VG ( Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil.); Brito CF ( Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil.); Teixeira AÉ ( Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.); Nunes GB ( Laboratory for Research in Experimental Neurochemistry, Federal University of Piauí, Teresina, PI, Brazil.); Camara CA ( Molecular Sciences Department, Federal Rural University of Pernambuco, Recife, PE, Brazil.); Filho JM ( Laboratory of Pharmaceutical Technology, Federal University of Paraiba, João Pessoa, PB, Brazil.); Gutierrez SJ ( Laboratory Chemistry of Bioactive Natural and Synthetic Products, Federal University of Piauí, Teresina, PI, Brazil.); Ribeiro RA ( Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.); Souza MH ( Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.); Barbosa AL ( Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil.); Freitas RM ( Laboratory for Research in Experimental Neurochemistry, Federal University of Piauí, Teresina, PI, Brazil.); Medeiros JV ( Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil. Electronic address: jandvenes@ufpi.edu.br.) |
| Abstract |
Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia, has been shown to have antioxidant activity and cytotoxicity in vitro. This study was aimed at evaluating the anti-inflammatory effect of riparin A against acute inflammation. The results of our evaluations in various experimental models indicated that riparin A reduced paw edema induced by carrageenan, compound 48/80, histamine, and serotonin. Furthermore, it decreased leukocyte and neutrophil counts, myeloperoxidase activity, thiobarbituric acid reactive substance (TBARS) levels, and cytokine (tumor necrosis factor- and interleukin-1ß) levels increased by carrageenan-induced peritonitis, and reversed glutathione levels. Riparin A also reduced carrageenan-induced adhesion and rolling of leukocytes on epithelial cells and did not produce gastric-damage as compared with indomethacin. In conclusion, the data show that riparin A reduces inflammatory response by inhibiting vascular and cellular events, modulating neutrophil migration, inhibiting proinflammatory cytokine production, and reducing oxidative stress. |
