NDLI: Suppression of hepatitis B virus-derived human hepatocellular carcinoma by NF-kappaB-inducing kinase-specific siRNA using liver-targeting liposomes.

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Suppression of hepatitis B virus-derived human hepatocellular carcinoma by NF-kappaB-inducing kinase-specific siRNA using liver-targeting liposomes.

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Suppression of hepatitis B virus-derived human hepatocellular carcinoma by NF-kappaB-inducing kinase-specific siRNA using liver-targeting liposomes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cho, Hyun-Ah Park, In-Sung Kim, Tae-Woo Oh, Yu-Kyoung Yang, Ki-Sook Kim, Jin-Seok
Description	Author Affiliation: Cho HA ( College of Pharmacy, Sookmyung Women's University, Seoul, 140-742, Korea.)
Abstract	Hepatitis B virus triggers an increase of NF-kappaB inducing kinase (NIK)-dependent NF-kappaB activation, followed by the promotion of hepatocellular carcinoma (HCC). Here, we examined the inhibitory effect of NIK-specific siRNA on NF-kappaB signaling and HCC. The results of this study indicated that these siRNAs suppressed HBV-derived HCC by regulating NIK activation. To exert a protective effect from degradation enzyme, cationic liposomes were contrived and modified to contain beta-sitosterol glucoside to target the asialoglycoprotein receptors in liver cancer cells. The cationic dimyristoyl diacyltrimethylammonium propane liposomes were prepared by a reverse-phase evaporation method with slight modification. beta-Sitosterol glucoside was added to the lipid mixture at the beginning of the liposome preparation for the purpose of liver targeting. These liposomes assisted the delivery of the siRNA to specific cells and protected it from various lyases, followed by the ultimate suppression of HCC.
File Format	HTM / HTML
ISSN	02536269
Issue Number	7
Volume Number	32
e-ISSN	19763786
Journal	Archives of Pharmacal Research
Language	English
Publisher	Springer
Publisher Date	2009-07-01
Publisher Place	Korea (South)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Carcinoma, Hepatocellular Therapy Genetic Therapy Methods Hepatitis B Virus Pathogenicity Liver Neoplasms Protein-serine-threonine Kinases Metabolism Rna Interference Rna, Small Interfering Transfection Asialoglycoprotein Receptor Enzymology Genetics Pathology Virology Cell Line, Tumor Cell Proliferation Cell Survival Hepatitis B Surface Antigens Immunology Humans Lipids Chemistry Liposomes Lyases Rna, Messenger Sitosterols Time Factors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Molecular Medicine

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