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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jeong, Nan-Hee Woo, Mi-Kyung Lee, Nak-Woo Hur, Sook-Jin Choi, Kum-Sook Kim, Hong-Jin |
| Spatial Coverage | Korea |
| Description | Author Affiliation: Jeong NH ( Department of Obstetrics and Gynecology, College of Medicine, Kyung-Hee University, Seoul, 130-702, Korea.) |
| Abstract | We aimed to determine the prevalence of HPV-16/18 antibodies in Korean women with high-grade cervical intraepithelial neoplasia (CIN) and cervical cancer. We conducted the hospital-based case-control study at the university hospital between 2003 and 2006. Cases were 130 high-grade CIN and 43 cervical cancer patients and the control group was 106 women showing normal cervical cytology. Enzyme-linked immunosorbent assays were performed for HPV-16/18 L1 virus-like particles (VLPs) as an antigen. Seropositivity for HPV-16 VLP and HPV-18 VLP was found in 67.4% and 30.2% of cancer patients and 59.2% and 20.0% of high-grade CIN patients, respectively. Seropositivity for HPV-16 with high-grade CIN (OR 6.91; 95% CI 3.74-12.76) and cervical cancer (OR 8.99; 95% CI 3.88-20.84) presented significant associations, as did seropositivity for HPV-18 (high-grade CIN: OR 3.64; 95% CI 1.67-7.95, cervical cancer: OR 6.82; 95% CI 2.52-18.45). Patients with both HPV-16 and 18 seropositivity were 9.38 times (95% CI 2.98-29.51) more likely to have high-grade CIN and 17.05 times (95% CI 4.55-63.87) more likely to have cancer. Both HPV 16 and 18 L1 VLP serology is the clear disease predictors of presence of high-grade CIN and cervical cancer. |
| File Format | HTM / HTML |
| ISSN | 02536269 |
| Issue Number | 7 |
| Volume Number | 32 |
| e-ISSN | 19763786 |
| Journal | Archives of Pharmacal Research |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2009-07-01 |
| Publisher Place | Korea (South) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Antibodies, Viral Blood Asian Continental Ancestry Group Capsid Proteins Immunology Cervical Intraepithelial Neoplasia Virology Human Papillomavirus 16 Human Papillomavirus 18 Uterine Cervical Neoplasms Adult Aged Case-control Studies Ethnology Pathology Enzyme-linked Immunosorbent Assay Female Humans Korea Epidemiology Middle Aged Prognosis Seroepidemiologic Studies Time Factors Virion Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Molecular Medicine |
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