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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kim, Junghyun Jang, Dae Sik Kim, Hyojun Kim, Jin Sook |
| Description | Author Affiliation: Kim J ( Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM), Daejeon, 305-811, Korea.) |
| Abstract | The aim of this study was to investigate the anti-obestic effects of ursolic acid isolated from the roots of Actinidia arguta, as well as the mechanism of action of this compound. This was conducted by testing whether ursolic acid inhibited the elevation of the rat plasma triacylglycerol levels after oral administration of a lipid emulsion containing corn oil in rats. Ursolic acid prevented the elevation of plasma triacylglycerol levels 2 h after oral administration of the lipid emulsion at a dose of 100 mg/kg. Furthermore, ursolic acid inhibited phosphodiesterase activity in vitro with an IC(50) of 51.21 muM and enhanced lipolysis in rat fat cells. We suggest that the inhibitory effects of ursolic acid, isolated from the roots of A. arguta, on obesity, might be attributable to the inhibition of lipid absorption through the inhibition of pancreatic lipase and by enhancing lipolysis in fat cells. |
| File Format | HTM / HTML |
| ISSN | 02536269 |
| Issue Number | 7 |
| Volume Number | 32 |
| e-ISSN | 19763786 |
| Journal | Archives of Pharmacal Research |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2009-07-01 |
| Publisher Place | Korea (South) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Actinidia Adipocytes Drug Effects Anti-obesity Agents Pharmacology Lipase Antagonists & Inhibitors Lipolysis Phosphodiesterase Inhibitors Triterpenes 1-methyl-3-isobutylxanthine Chemistry Enzymology Administration, Oral Animals Isolation & Purification Corn Oil Administration & Dosage Dose-response Relationship, Drug Lactones Metabolism Male Plant Roots Rats Rats, Wistar Time Factors Triglycerides Blood Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Molecular Medicine |
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