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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ho, Jeff C. H. Hsiao, C. D. Kawakami, K. Tse, William K. F. |
| Description | Country affiliation: Hong Kong Author Affiliation: Ho JC ( Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong.); Hsiao CD ( Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li, Taiwan.); Kawakami K ( Division of Molecular and Developmental Biology, National Institute of Genetics, Mishima, Japan.); Tse WK ( Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong. Electronic address: kftse@hkbu.edu.hk.) |
| Abstract | Triclosan (TCS) is an active antimicrobial ingredient used in many household products, such as skin creams and toothpaste. It is produced in high volumes, and humans are directly exposed to it and dispose it on a daily basis. TCS has been found to contaminate water worldwide. This study aimed to understand the potential developmental and metabolic abnormalities caused by TCS exposure by using zebrafish as the experimental model. Four developmental stages (70-85% epiboly, 10-12 somite, prim-5, and 5dpf) were selected to perform in situ hybridization staining to investigate the effects of TCS on dorsal ventral patterning, segmentation, brain development, and organ formation. Results showed, in terms of developmental toxicology, that neither phenotypic nor molecular changes were found after 5 days of 250µg/L TCS exposure. However, such dosage of TCS exposure resulted in lipid droplet accumulation in the yolk sac, which might due to the deregulated mRNA expression level of beta-oxidation transcripts. This study showed that 250µg/L TCS exposure does not affect normal embryogenesis or organogenesis; however, there are concerns regarding possible impairment of lipid metabolism. |
| File Format | HTM / HTML |
| ISSN | 0166445X |
| Journal | Aquatic Toxicology |
| Volume Number | 173 |
| e-ISSN | 18791514 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-04-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Lipid Metabolism Drug Effects Triclosan Toxicity Zebrafish Embryology Animals Water Pollutants, Chemical Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Aquatic Science |
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