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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Capaldo, Anna Gay, Flaminia Scudiero, Rosaria Trinchella, Francesca Caputo, Ivana Lepretti, Marilena Marabotti, Anna Esposito, Carla Laforgia, Vincenza |
| Spatial Coverage | Italy |
| Description | Author Affiliation: Capaldo A ( Department of Biology, University of Naples Federico II, Naples, Italy. Electronic address: anna.capaldo@unina.it.); Gay F ( Department of Chemistry and Biology, University of Salerno, Salerno, Italy.); Scudiero R ( Department of Biology, University of Naples Federico II, Naples, Italy.); Trinchella F ( Department of Biology, University of Naples Federico II, Naples, Italy.); Caputo I ( Department of Chemistry and Biology, University of Salerno, Salerno, Italy.); Lepretti M ( Department of Chemistry and Biology, University of Salerno, Salerno, Italy.); Marabotti A ( Department of Chemistry and Biology, University of Salerno, Salerno, Italy.); Esposito C ( Department of Chemistry and Biology, University of Salerno, Salerno, Italy.); Laforgia V ( Department of Biology, University of Naples Federico II, Naples, Italy.) |
| Abstract | The aim of this study was to verify if the freshwater safety values established from the European Community (1998) and the Italian Ministry of Health (2001) for cadmium (44.5nM/L in drinking water and 178nM/L in sewage waters) were safe for amphibians, since at these same concentrations cadmium induced endocrine disruption in the newt Triturus carnifex. Adult male specimens of T. carnifex were exposed daily to cadmium (44.5nM/L and 178nM/L as CdCl2, nominal concentrations), respectively, during 3- and 9-months; at the same time, control newts were exposed to tap water only. The accumulation of cadmium in the skin, liver and kidney, the levels of metallothioneins in the skin and the liver, the expression of metallothionein mRNA in the liver, as well as the presence of histological alterations and of apoptosis in the target organs were evaluated. The 9-months exposure induced cadmium accumulation in all the tissues examined; moreover, histological changes were observed in all the tissues examined, irrespective of the dose or the time of exposure. Apoptosis was only detected in the kidney, whereas metallothioneins and metallothionein mRNA did not increase. This study demonstrates that the existing chronic water quality criterion established for cadmium induces in the newt T. carnifex cadmium accumulation and histological alterations in the target organs examined. Together with our previous results, showing that, at these same concentrations, cadmium induced endocrine disruption, the present results suggest that the existing chronic water quality criterion for cadmium appears to be not protective of amphibians. |
| File Format | HTM / HTML |
| ISSN | 0166445X |
| Volume Number | 173 |
| e-ISSN | 18791514 |
| Journal | Aquatic Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-04-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Apoptosis Drug Effects Cadmium Toxicity Environmental Exposure Gene Expression Regulation Metallothionein Analysis Triturus Physiology Animals Metabolism Cadmium Chloride Endocrine Disruptors Italy Kidney Liver Male Genetics Skin Water Pollutants, Chemical Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Aquatic Science |
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