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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | He, Chengyong Zuo, Zhenghong Shi, Xiao Sun, Lingbin Wang, Chonggang |
| Description | Country affiliation: China Author Affiliation: He C ( State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.) |
| Abstract | Thyroid hormones play crucial roles in regulating development, morphogenesis, growth, and behavior in fishes. Some environmental pollutants have adverse effects on either development or function of the thyroid gland in fish. However, there are few reports on the effects of polycyclic aromatic hydrocarbons (PAHs) on fish thyroid. In the present study, rockfish (Sebastiscus marmoratus) embryos were exposed to pyrene (Py) for 5 days at the concentrations of 0.5, 5, and 50 nmol/L. The results showed that Py exposure decreased the expression of thyroid primordium markers, Pax2.1 and Nk2.1a as detected by quantitative PCR and in situ hybridization, and reduced the concentration of T(3), but not T(4). Thyroid receptor genes (TR and TRß) expression was down-regulated by Py. At the same time, Py exposure impaired the expression of thyroid development related genes, Fgfr2 and Hoxa3a expression, and altered the mRNA levels of thyroid function related genes, Deio1, Ttr, and Tg. In conclusion, the results demonstrated Py exposure inhibited thyroid development and influenced the function of thyroid system in rockfish embryos. |
| File Format | HTM / HTML |
| ISSN | 0166445X |
| Volume Number | 124-125 |
| e-ISSN | 18791514 |
| Journal | Aquatic Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-11-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Pyrenes Toxicity Thyroid Gland Drug Effects Water Pollutants, Chemical Animals Embryo, Nonmammalian Fish Proteins Genetics Metabolism Fishes Gene Expression Regulation Embryology Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Aquatic Science |
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