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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lee, Min-Chul Han, Jeonghoon Lee, Seung-Hwi Kim, Duck-Hyun Kang, Hye-Min Won, Eun-Ji Hwang, Dae-Sik Park, Jun Chul Om, Ae-Son Lee, Jae-Seong |
| Description | Country affiliation: South Korea Author Affiliation: Lee MC ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea.); Han J ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea.); Lee SH ( Department of Food and Nutrition, College of Health Science, Honam University, Gwangju 62399, South Korea); Kim DH ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea.); Kang HM ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea.); Won EJ ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea.); Hwang DS ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea.); Park JC ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea.); Om AS ( Department of Food and Nutrition, College of Human Ecology, Hanyang University, Seoul 04763, South Korea. Electronic address: aesonom@hanyang.ac.kr.); Lee JS ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea. Electronic address: jslee2@skku.edu.) |
| Abstract | De novo lipogenesis (DNL) is a fatty acid synthesis process that requires several genes, including sterol regulatory element binding protein (SREBP), ATP-citrate lyase (ACLY), and acetyl-CoA carboxylase (ACC). DNL up-regulation is able to induce fat accumulation through an increase in fatty acids. To investigate the relationship between DNL up-regulation and the accumulation of fatty acids and lipid droplets in response to 2,2',4,4' tetrabrominated diphenyl ether (BDE-47), we examined DNL in the copepod Tigriopus japonicus. Transcription levels of DNL-related genes were increased after exposure to 2.5µg/L BDE-47 for 24h. After exposure to 2.5µg/L BDE-47, palmitic acid was significantly increased (P<0.05) at days 1 and 4, along with upregulation of fatty acid synthesis-related genes (e.g., desaturases and elongases). However, docosahexaenoic acid and arachidonic acid were down-regulated at days 1 and 4, showing an antagonistic effect. Lipid droplet area significantly increased in Nile red staining analysis after 24h of exposure to 2.5µg/L BDE-47 in T. japonicus, while DNL was down-regulated in response to 500µM salicylate (a lipogenesis inhibitor), indicating that BDE-47 exposure is closely associated with an increase in fatty acids in this copepod. This study provides a better understanding of the effects of BDE-47 on DNL in copepods. |
| File Format | HTM / HTML |
| ISSN | 0166445X |
| Journal | Aquatic Toxicology |
| Volume Number | 178 |
| e-ISSN | 18791514 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-09-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Aquatic Science |
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