| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Lee, Min-Chul Puthumana, Jayesh Lee, Seung-Hwi Kang, Hye-Min Park, Jun Chul Jeong, Chang-Bum Han, Jeonghoon Hwang, Dae-Sik Seo, Jung Soo Park, Heum Gi Om, Ae-Son Lee, Jae-Seong |
| Description |
Country affiliation: South Korea Author Affiliation: Lee MC ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea.); Puthumana J ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea.); Lee SH ( Department of Food and Nutrition, College of Health Science, Honam University, Gwangju 62399, South Korea); Kang HM ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea.); Park JC ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea.); Jeong CB ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea.); Han J ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea.); Hwang DS ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea.); Seo JS ( Pathology Division, National Institute of Fisheries Science, Busan 46083, South Korea.); Park HG ( Department of Marine Bioscience, College of Life Sciences, Gangneung-Wonju National University, Gangneung 25457, South Korea.); Om AS ( Department of Food and Nutrition, College of Human Ecology, Hanyang University, Seoul 04763, South Korea. Electronic address: aesonom@hanyang.ac.kr.); Lee JS ( Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea. Electronic address: jslee2@skku.edu.) |
| Abstract |
Brominated flame retardant, 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47), has received grave concerns as a persistent organic pollutant, which is toxic to marine organisms, and a suspected link to endocrine abnormalities. Despite the wide distribution in the marine ecosystem, very little is known about the toxic impairments on marine organisms, particularly on invertebrates. Thus, we examined the adverse effects of BDE-47 on life history trait (development), oxidative markers, fatty acid composition, and lipid accumulation in response to BDE-47-induced stress in the marine copepod Paracyclopina nana. Also, activation level of mitogen-activated protein kinase (MAPK) signaling pathways along with the gene expression profile of de novo lipogenesis (DNL) pathways were addressed. As a result, BDE-47 induced oxidative stress (e.g. reactive oxygen species, ROS) mediated activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) signaling cascades in MAPK pathways. Activated MAPK pathways, in turn, induced signal molecules that bind to the transcription factors (TFs) responsible for lipogenesis to EcR, SREBP, ChREBP promoters. Also, the stress stimulated the conversion of saturated fatty acids (SFAs) to polyunsaturated fatty acids (PUFAs), a preparedness of the organism to adapt the observed stress, which could be correlated with the elongase and desaturase gene (e.g. ELO3, Δ5-DES, Δ9-DES) expressions, and then extended to the delayed early post-embryonic development and increased accumulation of lipid droplets in P. nana. This study will provide a better understanding of how BDE-47 effects on marine invertebrates particularly on the copepods, an important link in the marine food chain. |
| File Format |
HTM / HTML |
| ISSN |
0166445X |
| Journal |
Aquatic Toxicology |
| Volume Number |
181 |
| e-ISSN |
18791514 |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2016-12-01 |
| Publisher Place |
Netherlands |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Toxicology |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Health, Toxicology and Mutagenesis Aquatic Science |
