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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kanazawa, Hiromi Yoshida, Naohiro Shinnabe, Akihiro Iino, Yukiko |
| Description | Country affiliation: Japan Author Affiliation: Kanazawa H ( Department of Otolaryngology, Jichi Medical University Saitama Medical Center, Saitama, Japan.); Yoshida N ( Department of Otolaryngology, Jichi Medical University Saitama Medical Center, Saitama, Japan.); Shinnabe A ( Department of Otolaryngology, Jichi Medical University Saitama Medical Center, Saitama, Japan.); Iino Y ( Department of Otolaryngology, Jichi Medical University Saitama Medical Center, Saitama, Japan. Electronic address: yiino@jichi.ac.jp.) |
| Abstract | BACKGROUND: Eosinophilic otitis media (EOM) is an intractable otitis media characterized by a highly viscous effusion that contains eosinophils. We previously reported that high levels of IgE were detected in middle ear effusion (MEE) of patients with EOM. OBJECTIVE: To examine antigen-specific IgE in MEE of patients with EOM to clarify the pathogenesis of EOM. METHODS: Twenty-six patients with EOM associated with bronchial asthma were included in this study. Antigen-specific IgE against inhalant and bacterial antigens were measured in the serum and MEE of these patients. RESULTS: In patients with EOM, 1 or more antigen-specific IgEs were detected from the MEE of 16 of 26 patients (62%), whereas 1 of 9 control patients (11%) had antigen-specific IgE (P < .01). Total serum IgE concentrations were not different between the groups who tested positive (16 patients) and negative (10 patients) for antigen-specific IgE. None of the fungi-specific IgEs were detected in serum even though 11 patients tested positive for 1 or more fungal antigens detected in MEE. The severity score of EOM in the antigen-specific IgE-positive group was significantly higher than that in the antigen-specific IgE-negative group (P < .05). CONCLUSION: Antigen-specific IgE against inhalant and bacterial antigens may be locally produced in the middle ear mucosa in patients with EOM. In particular, local sensitization against fungi together with Staphylococcus aureus could result in local IgE production in the middle ear and may be responsible for the severity of EOM. |
| File Format | HTM / HTML |
| ISSN | 10811206 |
| Issue Number | 1 |
| Volume Number | 113 |
| e-ISSN | 15344436 |
| Journal | Annals of Allergy, Asthma & Immunology |
| Language | English |
| Publisher | Elsevier (on behalf of the American College of Allergy, Asthma and Immunology) |
| Publisher Date | 2014-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Antigens, Bacterial Immunology Antigens, Fungal Asthma Eosinophils Immunoglobulin E Blood Otitis Media With Effusion Adult Aged Complications Pathology Ear, Middle Female Fungi Humans Male Middle Aged Staphylococcus Aureus Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Immunology and Allergy Immunology |
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