NDLI: High blood eosinophil count is associated with more frequent asthma attacks in asthma patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tran, Trung N. Khatry, Deepak B. Ke, Xiongkan Ward, Christine K. Gossage, David
Spatial Coverage	United States
Description	Author Affiliation: Tran TN ( Observational Research Center, AstraZeneca, Gaithersburg, Maryland. Electronic address: trantr@medimmune.com.); Khatry DB ( Translational Sciences, MedImmune, Gaithersburg, Maryland.); Ke X ( Observational Research Center, AstraZeneca, Gaithersburg, Maryland.); Ward CK ( Translational Sciences, MedImmune, Gaithersburg, Maryland.); Gossage D ( Clinical Development, MedImmune, Gaithersburg, Maryland.)
Abstract	BACKGROUND: The clinical importance of eosinophils in asthma has been shown by the observation of frequent exacerbation in patients with high sputum eosinophil counts and a corresponding decrease in exacerbations when anti-inflammatory therapy was adjusted to maintain low sputum eosinophil percentages. However, less is known of the relation between blood eosinophilia and asthma exacerbation. OBJECTIVE: To examine whether patients with asthma and a higher blood eosinophil count have more asthma attacks than those with a lower count. METHODS: The authors analyzed data from the National Health and Nutrition Examination Survey, an annual cross-sectional survey of the US general population. Patients with asthma and asthma attacks were identified based on participants' self-report or parental report. A high blood eosinophil count was defined using 200, 300, or 400 cells/µL as cutoffs. The primary analysis used data from 2001 through 2010 after adjusting for demographic variables, obesity, smoking, neutrophil level, and past treatment for wheezing. A secondary analysis used data from 2007 through 2010 and included recent treatment for asthma and fraction of exhaled nitric oxide level as additional adjustment variables. RESULTS: In survey years 2001 through 2010, 3,162 patients with asthma had blood eosinophil data and approximately half (54% of children and 52% of adults) reported an asthma attack in the previous year. In the primary analysis, higher blood eosinophil counts were associated with more asthma attacks in children but not in adults. The secondary analysis suggested an association in both children and adults. CONCLUSION: Patients with asthma with higher blood eosinophil counts experienced more asthma attacks than those with lower eosinophil counts.
File Format	HTM / HTML
ISSN	10811206
Issue Number	1
Volume Number	113
e-ISSN	15344436
Journal	Annals of Allergy, Asthma & Immunology
Language	English
Publisher	Elsevier (on behalf of the American College of Allergy, Asthma and Immunology)
Publisher Date	2014-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Asthma Pathology Neutrophils Obesity Adolescent Adult Animals Anti-allergic Agents Therapeutic Use Drug Therapy Epidemiology Immunology Child Comorbidity Humans Leukocyte Count Middle Aged Neutrophil Infiltration Drug Effects Nutrition Surveys Respiratory Sounds Smoking United States Journal Article
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Immunology and Allergy Immunology

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