| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Zoratti, Edward Havstad, Suzanne Wegienka, Ganesa Nicholas, Charlotte Bobbitt, Kevin R. Woodcroft, Kimberley J. Ownby, Dennis R. Johnson, Christine Cole |
| Description |
Author Affiliation: Zoratti E ( Division of Allergy and Immunology, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan. Electronic address: ezoratt1@hfhs.org.); Havstad S ( Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan.); Wegienka G ( Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan.); Nicholas C ( Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan.); Bobbitt KR ( Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan.); Woodcroft KJ ( Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan.); Ownby DR ( Division of Allergy and Immunology, Department of Pediatrics, Georgia Regents University, Augusta, Georgia.); Johnson CC ( Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan.) |
| Abstract |
BACKGROUND: Recent research has emphasized the need to better discriminate asthma phenotypes and consider underlying mechanistic endotypes in epidemiologic and clinical studies. Although allergic asthma and nonallergic asthma are frequently combined into 1 disease category in observational research and clinical trials, few studies have investigated the extent to which these 2 separate phenotypes are associated with distinct cytokine immunologic profiles in a representative young adult population. OBJECTIVE: To investigate the cytokine production-based endotypes underlying the clinical phenotypes of allergic and nonallergic asthma in a population-based birth cohort evaluated as young adults. METHODS: Participants included 18- to 21-year-old members (n = 540) of a suburban Detroit birth cohort study, the Childhood Allergy Study. Phorbol myristate acetate-stimulated whole blood interleukin (IL)-4, IL-5, IL-10, IL-12, IL-13, IL-17A, IL-17F, IL-22, and interferon-γ secretory responses were analyzed for associations comparing participants with allergic vs nonallergic asthma phenotypes with those without asthma. RESULTS: T-helper cell type (TH) 2-polarized responses, measured as higher mean IL-5 and IL-13 secretions and lower ratios of interferon-γ and IL-12 to 3 TH2 cytokines (IL-4, IL-5, or IL-13), were observed only in participants with allergic asthma. Nonallergic asthma was associated with TH1-polarized responses, including higher adjusted interferon-γ secretion compared with participants with allergic asthma and, surprisingly, those without asthma (odds ratio 2.5, confidence interval 1.2-5.1, P < .01). CONCLUSION: As expected, young adults with a history of an allergic asthma phenotype exhibited a TH2-polarized cytokine response after polyclonal stimulation. However, TH1 polarization was observed in patients with a history of nonallergic asthma. Allergic and nonallergic asthma are associated with etiologically distinct immune endotypes, underscoring the importance of discriminating these endotypes in research analyses and clinical management. |
| File Format |
HTM / HTML |
| ISSN |
10811206 |
| e-ISSN |
15344436 |
| DOI |
10.1016/j.anai.2014.04.013 |
| Journal |
Annals of Allergy, Asthma & Immunology |
| Issue Number |
1 |
| Volume Number |
113 |
| Language |
English |
| Publisher |
Elsevier (on behalf of the American College of Allergy, Asthma and Immunology) |
| Publisher Date |
2014-07-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Discipline Immunology Asthma Classification Diagnosis Cytokines Immunology Th1 Cells Pathology Th2 Cells Adolescent Case-control Studies Biosynthesis Odds Ratio Primary Cell Culture Tetradecanoylphorbol Acetate Pharmacology Drug Effects Th1-th2 Balance Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Pulmonary and Respiratory Medicine Immunology and Allergy Immunology |
