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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kalliokoski, Otto Jacobsen, Kirsten R. Hau, Jann Abelson, Klas S. P. |
| Description | Country affiliation: Denmark Author Affiliation: Kalliokoski O ( Department of Experimental Medicine, University and University Hospital of Copenhagen, Copenhagen, Denmark.) |
| Abstract | Buprenorphine is the most commonly used drug for peri-operative pain relief in laboratory rodents. The systemic concentrations of buprenorphine were measured in mice following administration intravenously (i.v.), subcutaneously (s.c.), orally by gavage and by voluntary ingestion, to determine the post-administration serum concentration of buprenorphine. Voluntarily ingested buprenorphine resulted in long-lasting high serum concentrations, as did oral gavage administration (24 h serum concentration: 110 ng h/mL for both routes of administration). In contrast, buprenorphine administered parenterally remained in the circulation for a substantially shorter time (24 h serum concentration for i.v. and s.c. were 40 ng h/mL and 30 ng h/mL, respectively). This marked difference was probably due to the higher dose used for oral administration, which is regarded necessary for sufficient analgesic effect, and to the slower absorption of the oral boli, as well as saturation of the hepatic buprenorphine metabolising pathways. Voluntary ingestion of buprenorphine was found to constitute a practical way to provide laboratory mice with efficient pain relief. |
| File Format | HTM / HTML |
| ISSN | 10900233 |
| Issue Number | 2 |
| Volume Number | 187 |
| e-ISSN | 15322971 |
| Journal | The Veterinary Journal |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Eating Research Support, Non-u.s. Gov't Analgesics, Opioid Injections, Intravenous Administration, Oral Drug Therapy Discipline Veterinary Medicine Male Administration & Dosage Mice, Inbred Strains Blood Journal Article Animals Pain Buprenorphine Time Factors Injections, Subcutaneous Mice |
| Content Type | Text |
| Resource Type | Article |
| Subject | Veterinary Animal Science and Zoology |
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