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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kwasa, E. A. Vinayak, S. Armstrong, R. |
| Description | Country affiliation: Kenya Author Affiliation: Kwasa EA ( Aga Khan University Hospital, Nairobi, Kenya.) |
| Abstract | OBJECTIVE: Global incidence of contrast-induced nephropathy (CIN) is 2-5%, but a recent Kenyan study highlighted a local incidence of 12-14% without offering an explanation for the higher incidence. This study proposes that inflammatory states confer a higher relative risk for development of CIN. Our objective was to determine the risk of developing CIN given the presence of an inflammatory state in patients in Kenya. METHODS: Prospective cohort study of patients undergoing a contrast-enhanced CT (CECT) scan in a private university teaching hospital in Kenya and having no known risk factors for CIN. 423 patients were recruited and grouped into those without inflammation (unexposed) having serum C-reactive protein (CRP) levels ≤5 mg dl(-1) and those with evidence of inflammation having CRP levels >5 mg dl(-1). Serum creatinine (SCr) was measured before the CECT and 48 h following the CECT with CIN diagnosed by an increase of >25% in the SCr from the baseline. Relative risk was determined and multiple logistic regression analysis performed on biophysical variables and contrast volume to assess their effect on development of CIN. RESULTS: Patients with high CRP levels had a relative risk of developing CIN of 2.16 compared with those with normal levels of CRP (p = 0.016). No statistically significant association was seen between biophysical variables or volume of contrast and development of CIN. CONCLUSION: Ongoing inflammation doubles the likelihood of development of CIN. ADVANCES IN KNOWLEDGE: This study highlights the importance of inflammation as a risk factor in the development of CIN. |
| File Format | HTM / HTML |
| ISSN | 00071277 |
| DOI | 10.1259/bjr.20130738 |
| Journal | The British Journal of Radiology |
| Issue Number | 1041 |
| Volume Number | 87 |
| Language | English |
| Publisher | BIR Publications |
| Publisher Date | 2014-09-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Kidney Diseases Research Support, Non-u.s. Gov't Adverse Effects Prospective Studies Risk Factors Logistic Models Inflammation Chemically Induced Physiopathology Radiography Contrast Media C-reactive Protein Discipline Radiology |
| Content Type | Text |
| Resource Type | Article |
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