NDLI: N,N-dimethylacetamide regulates the proinflammatory response associated with endotoxin and prevents preterm birth.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sundaram, Sruthi Ashby, Charles R. Pekson, Ryan Sampat, Vaishali Sitapara, Ravikumar Mantell, Lin Chen, Chih-Hung Yen, Haoting Abhichandani, Khushboo Munnangi, Swapna Khadtare, Nikhil Stephani, Ralph A. Reznik, Sandra E.
Description	Country affiliation: United States Author Affiliation: Sundaram S ( Department of Pharmaceutical Sciences, St. John's University, Queens, New York 11439, USA.)
Abstract	The proinflammatory response leads to various types of pathologic pathways, including the development of preterm birth. Preterm birth occurs in 12% of deliveries in the United States and causes more than 70% of perinatal morbidity and mortality. The most common cause of spontaneous preterm birth is intrauterine infection in the mother. There is accumulating evidence indicating that the release of proinflammatory cytokines plays a critical role in the pathogenesis of inflammation-associated premature delivery. We found that the common organic solvent, N,N-dimethylacetamide (DMA), prevents endotoxin-induced preterm birth in timed pregnant C57BL/6 embryonic day (E)15.5 mice and rescues their pups from spontaneous abortion at doses many-fold lower than those currently used clinically and in a dose-dependent fashion. We also provide histologic evidence that DMA suppresses the endotoxin-triggered proinflammatory response by significantly attenuating inflammatory cell infiltration of placental tissue. Furthermore, immunoblotting analysis of placental tissue harvested from our murine models revealed DMA-mediated regulation of expression of the proinflammatory cytokines IL-1ß, tumor necrosis factor , and IL-6, and increased expression of the regulatory inflammatory cytokine IL-10. By using in vitro studies, we provide evidence that DMA suppresses macrophage function and that this small molecule prevents nuclear translocation of nuclear factor-kB. These results suggest that DMA represents a newly discovered, nontoxic therapy for a broad range of inflammatory disorders.
File Format	HTM / HTML
ISSN	00029440
e-ISSN	15252191
DOI	10.1016/j.ajpath.2013.05.006
Journal	The American Journal of Pathology
Issue Number	2
Volume Number	183
Language	English
Publisher	Elsevier (on behalf of the American Society for Investigative Pathology)
Publisher Date	2013-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Research Support, N.i.h., Extramural Nf-kappa B Premature Birth Cytokines Toxicity Prevention & Control Mice, Inbred C57bl Endotoxins Discipline Pathology Pharmacology Drug Effects Chemically Induced Lipopolysaccharides Pregnancy Animals Anti-inflammatory Agents Mice Acetamides
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine

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