NDLI: Milky spots promote ovarian cancer metastatic colonization of peritoneal adipose in experimental models.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Clark, Robert Krishnan, Venkatesh Schoof, Michael Rodriguez, Irving Theriault, Betty Chekmareva, Marina Rinker-Schaeffer, Carrie
Description	Country affiliation: United States Author Affiliation: Clark R ( Department of Pathology-Molecular Pathogenesis and Molecular Medicine, The University of Chicago, Chicago, Illinois 60637, USA.)
Abstract	The goal of controlling ovarian cancer metastasis formation has elicited considerable interest in identifying the tissue microenvironments involved in cancer cell colonization of the omentum. Omental adipose is a site of prodigious metastasis in both ovarian cancer models and clinical disease. This tissue is unusual for its milky spots, comprised of immune cells, stromal cells, and structural elements surrounding glomerulus-like capillary beds. The present study shows the novel finding that milky spots and adipocytes play distinct and complementary roles in omental metastatic colonization. In vivo assays showed that ID8, CaOV3, HeyA8, and SKOV3ip.1 cancer cells preferentially lodge and grow within omental and splenoportal fat, which contain milky spots, rather than in peritoneal fat depots. Similarly, medium conditioned by milky spot-containing adipose tissue caused 75% more cell migration than did medium conditioned by milky spot-deficient adipose. Studies with immunodeficient mice showed that the mouse genetic background does not alter omental milky spot number and size, nor does it affect ovarian cancer colonization. Finally, consistent with the role of lipids as an energy source for cancer cell growth, in vivo time-course studies revealed an inverse relationship between metastatic burden and omental adipocyte content. Our findings support a two-step model in which both milky spots and adipose have specific roles in colonization of the omentum by ovarian cancer cells.
File Format	HTM / HTML
ISSN	00029440
e-ISSN	15252191
DOI	10.1016/j.ajpath.2013.04.023
Journal	The American Journal of Pathology
Issue Number	2
Volume Number	183
Language	English
Publisher	Elsevier (on behalf of the American Society for Investigative Pathology)
Publisher Date	2013-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s. Research Support, Non-u.s. Gov't Coloring Agents Discipline Pathology Omentum Azure Stains Pathology Peritoneal Neoplasms Animals Tissue And Organ Harvesting Cell Line, Tumor Mice Ovarian Neoplasms Adipose Tissue Disease Models, Animal
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine

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