NDLI: N,N-Dimethylacetamide Regulates the Proinflammatory Response Associated with Endotoxin and Prevents Preterm Birth

Content Provider	PubMed Central
Author	Sundaram, Sruthi Ashby, Charles R. Ryan, Pekson Sampat, Vaishali Ravikumar, Sitapara Mantell, Lin Chen, Chih-hung Yen, Haoting Abhichandani, Khushboo Munnangi, Swapna Nikhil, Khadtare Stephani, Ralph A. Reznik, Sandra E.
Copyright Year	2013
Abstract	The proinflammatory response leads to various types of pathologic pathways, including the development of preterm birth. Preterm birth occurs in 12% of deliveries in the United States and causes more than 70% of perinatal morbidity and mortality. The most common cause of spontaneous preterm birth is intrauterine infection in the mother. There is accumulating evidence indicating that the release of proinflammatory cytokines plays a critical role in the pathogenesis of inflammation-associated premature delivery. We found that the common organic solvent, N,N-dimethylacetamide (DMA), prevents endotoxin-induced preterm birth in timed pregnant C57BL/6 embryonic day (E)15.5 mice and rescues their pups from spontaneous abortion at doses many-fold lower than those currently used clinically and in a dose-dependent fashion. We also provide histologic evidence that DMA suppresses the endotoxin-triggered proinflammatory response by significantly attenuating inflammatory cell infiltration of placental tissue. Furthermore, immunoblotting analysis of placental tissue harvested from our murine models revealed DMA-mediated regulation of expression of the proinflammatory cytokines IL-1β, tumor necrosis factor α, and IL-6, and increased expression of the regulatory inflammatory cytokine IL-10. By using in vitro studies, we provide evidence that DMA suppresses macrophage function and that this small molecule prevents nuclear translocation of nuclear factor-kB. These results suggest that DMA represents a newly discovered, nontoxic therapy for a broad range of inflammatory disorders.
Related Links	http://dx.doi.org/10.1016/j.ajpath.2013.05.006
Ending Page	430
Page Count	9
Starting Page	422
File Format	PDF
ISSN	00029440
e-ISSN	15252191
Journal	The American Journal of Pathology
Issue Number	2
Volume Number	183
Language	English
Publisher	American Society for Investigative Pathology
Publisher Date	2013-08-01
Access Restriction	Open
Rights Holder	American Society for Investigative Pathology
Subject Keyword	Pathology and Forensic Medicine Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine

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