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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Comeau, Wendy L. Lee, Kristen Anderson, Katie Weinberg, Joanne |
| Description | Author Affiliation: Comeau WL ( Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver V6T 1Z3, Canada. Electronic address: comeauwe@mail.ubc.ca.); Lee K ( Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver V6T 1Z3, Canada.); Anderson K ( Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver V6T 1Z3, Canada.); Weinberg J ( Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver V6T 1Z3, Canada.) |
| Abstract | Abnormal activity of stress hormone (hypothalamic-pituitary-adrenal [HPA]), and gonadal hormone (hypothalamic-pituitary-gonadal [HPG]) systems is reported following prenatal alcohol exposure (PAE). PAE increases vulnerability of brain regions involved in regulation of these systems to stressors or challenges during sensitive periods of development, such as adolescence. In addition, HPA and HPG functions are linked to higher order functions such as executive function (EF), with dysregulation of either system adversely affecting EF processes, including attention and response inhibition, that influence cognition. However, how HPA and HPG systems interact to influence cognitive performance in individuals with an FASD is not fully understood. To investigate, we used a rat model of moderate PAE. Adolescent female PAE and control offspring were exposed to 10days of chronic mild stress (CMS) and cognitive function was assessed on the radial arm maze (RAM) in adulthood. On the final test day, animals were sacrificed, with blood collected for hormone analyses, and vaginal smears taken to assess estrus stage at the time of termination. Analyses showed that adolescent CMS significantly increased levels of CORT and RAM errors during proestrus in adult PAE but not control females. Moreover, CORT levels were correlated with estradiol levels and with RAM errors, but only in PAE females, with outcome dependent on adolescent CMS condition. These results suggest that PAE increases sensitivity to the influences of stress and gonadal hormones on cognition, and thus, in turn, that HPA and HPG dysregulation may underlie some of the deficits in executive function described previously in PAE females. |
| File Format | HTM / HTML |
| ISSN | 00319384 |
| e-ISSN | 1873507X |
| DOI | 10.1016/j.physbeh.2015.02.033 |
| Journal | Physiology & Behavior |
| Volume Number | 148 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Research Support, N.i.h., Extramural Prenatal Exposure Delayed Effects Toxicity Corticosterone Estradiol Blood Discipline Physiology Time Factors Etiology Physiology Estrous Cycle Animals, Newborn Ethanol Rats, Sprague-dawley Drug Effects Physiopathology Pregnancy Animals Maze Learning Central Nervous System Depressants Cognition Disorders Sex Factors Stress, Psychological Analysis Of Variance Discipline Behavioral Neuroscience |
| Content Type | Text |
| Resource Type | Article |
| Subject | Experimental and Cognitive Psychology Behavioral Neuroscience |
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