NDLI: Stress-induced suppression of hippocampal neurogenesis in adult male rats is altered by prenatal ethanol exposure.

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Stress-induced suppression of hippocampal neurogenesis in adult male rats is altered by prenatal ethanol exposure.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sliwowska, J. H. Barker, J. M. Barha, C. K. Lan, N. Weinberg, J. Galea, L. A. M.
Description	Country affiliation: Canada Author Affiliation: Sliwowska JH ( Department of Cellular and Physiological Sciences, The University of the British Columbia, Vancouver, BC, V6T 1Z3, Canada. sliwowsk@interchange.ubc.ca)
Abstract	In adulthood, both alcohol (ethanol) and stress are known to suppress hippocampal neurogenesis in male rats. Similarly, most studies report that prenatal alcohol exposure (PAE) reduces cell proliferation and/or cell survival in the hippocampus of adult males. Furthermore, PAE is known to have marked effects on behavioral and hypothalamic-pituitary-adrenal (HPA) responsiveness to stressors. However, no studies have examined the modulation of adult hippocampal neurogenesis by stress in PAE animals. We hypothesized that, in accordance with previous data, PAE would suppress basal levels of adult hippocampal neurogenesis, and further that stress acting on a sensitized HPA axis would have greater adverse effects on adult hippocampal neurogenesis in PAE than in control rats. Adult male offspring from PAE, pair-fed (PF) control, and ad libitum-fed control (C) groups were subjected to restraint stress (9 days, 1 h/day) or left undisturbed. Rats were then injected with bromodeoxyuridine (BrdU) on day 10, perfused 24 h (proliferation) or 3 weeks (survival) later, and brains processed for BrdU immunohistochemistry. We found that (1) under non-stressed conditions, PAE rats had a small but statistically significant suppressive effect on levels of hippocampal neurogenesis and (2) unexpectedly, repeated restraint stress significantly reduced neurogenesis in C and PF, but not PAE rats. We speculate that the failure of PAE males to mount an appropriate (i.e. suppressive) neurogenic response to stressors, implies reduced plasticity and adaptability or resilience, which could impact negatively on hippocampal structure and function.
File Format	HTM / HTML
ISSN	10253890
e-ISSN	16078888
DOI	10.3109/10253890903531582
Journal	Stress
Issue Number	4
Volume Number	13
Language	English
Publisher	Taylor & Francis
Publisher Date	2010-07-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Neurology Ethanol Pharmacology Hippocampus Physiopathology Prenatal Exposure Delayed Effects Stress, Psychological Animals Corticosterone Metabolism Drug Effects Hypothalamo-hypophyseal System Neurons Physiology Pituitary-adrenal System Pregnancy Rats, Sprague-dawley Restraint, Physical Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Endocrine and Autonomic Systems Behavioral Neuroscience Neuropsychology and Physiological Psychology Psychiatry and Mental Health

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